持续气道正压通气联合化痰补肾法治疗OSAHS合并轻度认知功能障碍的临床疗效

The clinical efficacy of continuous positive airway pressure ventilation combined with resolving phlegm and tonifying the kidney in the treatment of OSAHS with mild cognitive impairment

目的探讨持续正压通气(CPAP)联合化痰补肾法治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并轻度认知功能障碍的临床疗效。方法66例OSAHS合并轻度认知功能障碍患者采用随机数字表法均分为对照组和观察组;对照组患者采用CPAP治疗,观察组患者采用CPAP联合化痰补肾法治疗,比较2组患者治疗前和治疗3个月时的血氧饱和度(LSaO_(2))、呼吸暂停低通气指数(AHI)、舒张压、收缩压、蒙特利尔认知评估量表(MoCA)评分、Epworth嗜睡量表(ESS)评分。结果治疗前,2组患者的AHI、LSaO_(2)、收缩压、舒张压、ESS及MoCA评分比较,差异无统计学意义(P>0.05);2组患者治疗3个月时的AHI、收缩压、舒张压及ESS评分较治疗前降低,LSaO_(2)及MoCA评分较治疗前升高,差异有统计学意义(P<0.05);且观察组患者治疗3个月时的AHI、收缩压、舒张压及ESS评分水平低于对照组患者,LSaO_(2)、MoCA评分高于对照组患者,差异有统计学意义(P<0.05)。结论CPAP联合化痰补肾法可有效改善OSAHS合并轻度认知功能障碍患者的临床症状,有利于患者认知功能的恢复。

Objective To explore the clinical efficacy of continuous positive airway pressure(CPAP)ventilation combined with resolving phlegm and tonifying the kidney in the treatment of obstructive sleep apnea hypopnea syndrome(OSAHS)with mild cognitive impairment.Methods Sixty-six patients with OSAHS with mild cognitive impairment were randomly divided into control group and observation group.Patients in the controlgroup were treated with CPAP ventilation,and patients in the observation group were treated with CPAP ventilation combined with resolving phlegm and tonifying the kidney.The course of treatment of the two groups was 3 months.The LSaO_(2),AHI,diastolic blood pressure,systolic blood pressure,MoCA score,and ESS score of patients in the two groups were compared before and 3 months after treatment.Results Before treatment,the AHI,LSaO_(2),systolic blood pressure,diastolic blood pressure,ESS,and MoCA scores of the two groups were not statistically different(P>0.05).After 3 months of treatment,the AHI,systolic blood pressure,diastolic blood pressure,and ESS scores of the two groups were significantly lower than those before treatment,LSaO_(2),and MoCA scores were significantly higher than those before treatment,and the difference was statistically significant(P<0.05).After 3 months of treatment,the AHI,systolic blood pressure,diastolic blood pressure,and ESS score levels of patients in the observation group were significantly lower than those in the control group,the scores of LSaO_(2),and MoCA were significantly higher than those in the control group,and the difference was statistically significant(P<0.05).Conclusion CPAP ventilation combined with the method of resolving phlegm and tonifying the kidney can effectively improve the clinical symptoms of patients with OSAHS and mild cognitive impairment,which is beneficial to the recovery of cognitive function.