寻找针灸的移动靶点:为什么是肥大细胞?

In the search of mobile target for acupuncture:why is mast cell?

针灸临床实践和基础研究都支持针灸治疗有特异性的组织和细胞靶点。除了已知的神经和血管等固定组织外,笔者通过分析皮肤其他常驻细胞的生物学特征,提出皮肤肥大细胞较符合针灸的移动靶点,并提出针刺的仿生原理假说,以解释人体非特异性免疫和愈合系统对针刺反应的生物学原理。皮肤肥大细胞在人体分布呈"行于端,聚于窍"的特征,其密度与穴位密度及微针系统高度相关。这些证据都支持肥大细胞是针灸的移动靶细胞,可解释针灸的部分现象及原理,还可作为穴位组织标识之一。

Both clinical practice and basic research of acupuncture have pointed out that acupuncture treatment has specific tissue and cellular targets.In addition to the known fixed tissue targets such as nerves and blood vessels,the author analyzes the biological characteristics of other skin resident cells in the skin and concludes that cutaneous mast cells are the most suitable candidate for the cellular target of acupuncture.A hypothesis of the bionic acupuncture is proposed to explain the biological principles by which the innate immunity and healing system respond to acupuncture.The distribution of mast cells in the human skin is characterized by"approaching to the terminals and gathering at the orifices",and the cell density is highly correlated with the density of acupoints and the micro-acupuncture systems.These evidences all support that mast cells are the mobile target cells for acupuncture,which can explain some clinical phenomena and principles of acupuncture,and suggest mast cells as one of the tissue markers for acupoints.