基于文献挖掘《中医方剂大辞典》治疗食欲不振用药规律探讨

Discussion on Medication Rules of Anorexia Treated by“Dictionary of Traditional Chinese Medicine Prescriptions”Based on Literature Mining

目的:探讨《中医方剂大辞典》中食欲不振的用药规律,为当代中医辨治用药时提供借鉴和参考。方法:统计《中医方剂大辞典》中食欲不振使用药物情况,并分别查出其方、药(药性、药味、功效及归经),运用软件Excel 2010建立并输入方、药相关数据的原始数据库;并把相关药物的频次运用软件SPSS 22.0做描述性的统计;对于药物间潜在关联规则使用软件Weka 3.8进行挖掘及分析同时采用软件Cytoscape 3.6.1把所得出药物间的关联规则制作成网络视图。结果:《中医方剂大辞典》中治疗食欲不振的高频药物有甘草、陈皮、茯苓、白术、人参等;其中以补虚药居多,依次为化湿药、理气药、温里药和消食药,药性多为温性及平性,药味多属辛味、甘味及苦味,归经多属脾胃经。依据高频药物的关联规则分析,得到药对配伍规则如陈皮-甘草配伍最多,其次是茯苓-甘草、茯苓-白术、茯苓-陈皮、白术-甘草等;在此基础上进行层次聚类得到新方5首。结论:数据挖掘结果发现《中医方剂大辞典》中治疗食欲不振多用健脾益气、消食和胃、理气消痞、温中燥湿等治法,可为当代医家在临床临证施治用药上提供参考。

Objective To explore the law of medication for anorexia in the Dictionary of Traditional Chinese Medicine Prescriptions,so as to provide references and references for clinical medication of contemporary Chinese physicians.Method According to the statistics of appetite deprivation drugs used in the Dictionary of Traditional Chinese Medicine Prescriptions,the prescriptions and medicines(medicinal properties,taste,efficacy and meridian tropism)were found out respectively.Using Excel 2010 design to establish the original database and input relevant data,using SPSS 22.0 software to describe the frequency of drugs,using Weka 3.8 software to mine and analyze potential association rules between drugs,and using Cytoscape 3.6.1 software to display the association rules between drugs on the network visually.Results In the Dictionary of Traditional Chinese Medicine Prescriptions,the high-frequency medicines for anorexia are licorice,tangerine peel,Poriacocos,Atractylodesmacrocephala,ginseng,Magnolia officinalis,Shenqu,dried ginger,malt,nutmeg,etc.They are mostly deficiency tonics,dampness-removing drugs,Qi-Regulating drugs,warming-li medicines and edible medicines,with mild and mild nature,bitter and bitter taste,and belong to the spleen-stomach meridian.According to the analysis of association rules of high frequency drugs,the most compatibility rules were obtained,such as orange peel-licorice,Poriacocos-licorice,Poriacocos-atractylodesmacrocephala,Poriacocos-tangerine peel,Atractylodesmacrocephala-licorice,etc.On this basis,five new rules were obtained by hierarchical clustering.Conclusion Data mining results show that in the Dictionary of Traditional Chinese Medicine Prescriptions,the treatments of anorexia include invigorating the spleen and invigorating qi,digestion and stomach,regulating qi and eliminating rubella,warming and dryness and dampness.It has a certain guiding significance for contemporary physicians in clinical treatment based on differentiation of symptoms and signs.