美托洛尔联合依那普利治疗心力衰竭的临床疗效

Clinical efficacy of metoprolol combined with enalapril in the treatment of heart failure

目的探讨美托洛尔联合依那普利治疗心力衰竭的临床疗效。方法选取团风县中医医院2018年3月—2019年12月收治的心力衰竭患者82例,按照计算机随机法分为对照组与观察组,各41例。对照组予以依那普利治疗,观察组在对照组基础上予以美托洛尔治疗。比较2组临床疗效,治疗前后心功能指标[心排血量(CO)、左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)]、6 min步行距离、血浆脑钠肽(BNP)、肌钙蛋白I(cTnI),并观察2组不良反应发生情况。结果观察组治疗总有效率高于对照组(P<0.05)。治疗前2组CO、LVEF、LVEDD、6 min步行距离、BNP、cTnI比较,差异无统计学意义(P>0.05);治疗后观察组CO、LVEF高于对照组,LVEDD、BNP、cTnI低于对照组,6 min步行距离长于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论美托洛尔联合依那普利治疗心力衰竭的临床疗效确切,可有效改善心功能,减轻心肌损伤,且安全性较高。

Objective To explore the clinical efficacy of metoprolol combined with enalapril in the treatment of heart failure.Methods A total of 82 cases of patients with heart failure were selected from March 2018 to December 2019 in Tuanfeng County Hospital of Traditional Chinese Medicine,which were divided into control group and observation group according to computer random method,with 41 cases in each group.The control group was treated with enalapril,the observation group was treated with metoprolol on the basis of the control group.Clinical efficacy,cardiac function indexes(CO,LVEF,LVEDD),6 min walking distance,BNP,cTnI before and after treatment were compared between the two groups,and the incidence of adverse reactions were observed.Results The total effective rate of observation group was higher than that of control group(P<0.05).Before treatment,there was no significant difference in CO,LVEF,LVEDD,6 min walking distance,BNP and cTnI between the two groups(P>0.05);after treatment,the observation group of CO and LVEF were higher than control group,LVEDD,BNP and cTnI were lower than control group,and the 6 min walking distance was longer than control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Metoprolol combined with enalapril have an exact clinical effect for heart failure,which can effectively improve heart function and reduce myocardial injury,and with high safety.