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HER2过表达型乳腺癌KIF20A的表达和临床意义 被引量:1

Expression and clinical significance of KIF20A in HER2-positive breast cancer
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摘要 目的探讨驱动蛋白家族成员20A(KIF20A)在人表皮生长因子受体2(HER2)过表达型乳腺癌中的表达和临床意义。方法回顾性分析82例HER2过表达型乳腺癌病例的临床病理特征资料。用免疫组织化学的方法检测组织中KIF20A的表达,分析HER2过表达型乳腺癌中KIF20A的表达及与临床病理特征的关系。通过生物信息学的方法分析KIF20A在HER2过表达型乳腺癌组织及癌旁正常组织中的mRNA水平,并分析其表达与患者的生存率间的关系。结果KIF20A的阳性表达在胞核,成棕黄色颗粒。在HER2过表达型乳腺癌组织中,KIF20A阳性高表达率为57.3%,而在癌旁组织中主要是低表达或无表达。KIF20A高表达与肿瘤大小和pTNM分期显著相关,而与年龄和肿瘤分级的相关性无统计学意义。生物信息学分析结果提示侵袭性乳腺癌中KIF20A高表达与不良的无疾病生存期显著相关。结论KIF20A在HER2过表达型乳腺癌中存在异常表达,与HER2过表达型乳腺癌肿瘤分级和pTNM分期相关,并且KIF20A高表达提示预后不良。 Objective To explore the expression and clinical significance of KIF20A in HER2-positive breast cancer.Methods The clinicopathological characteristics of 82 cases of HER2-positive breast cancer were retrospectively analyzed.The expression of KIF20A in tissues was detected by immunohistochemical method,and the expression of KIF20A in HER2 overexpression breast cancer and its relationship with clinicopathological characteristics were analyzed.The mRNA level of KIF20A in HER2-positive breast cancer tissues and normal tissues adjacent to cancer were analyzed by bioinformatics methods.Results The positive expression of KIF20A was in the nucleus,forming brown-yellow particles.In HER2-positive breast cancer tissues,the positive high expression rate of KIF20A is 57.3%,while it is mainly low or no expression in the adjacent tissues.The high expression of KIF20A is significantly correlated with tumor size and pTNM stage,while the correlation with age and tumor grade is not statistically significant.The results of bioinformatics analysis suggest that the high expression of KIF20A in invasive breast cancer is significantly related to poor disease-free survival.Conclusions KIF20A is abnormally expressed in HER2-positive breast cancer,which is related to the tumor grade and pTNM stage of HER2 overexpression breast cancer,and the high expression of KIF20A indicates a poor prognosis.
作者 王艳丽 张爱民 常艳敏 Wang Yanli;Zhang Aimin;Chang Yanmin(Department of Laboratory,Tianjin Nankai Hospital,Tianjin 300100,China)
出处 《国际生物医学工程杂志》 CAS 2021年第3期198-201,217,共5页 International Journal of Biomedical Engineering
关键词 HER2过表达型乳腺癌 KIF20A 乳腺癌 TNM分期 预后 HER2-positive breast cancer KIF20A Breast cancer TNM stage Prognosis
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