保妇康栓在慢性宫颈炎合并HPV持续感染治疗中的效果分析

Effect analysis of Baofukang suppository in the treatment of chronic cervicitis complicated with persistent HPV infection

目的探讨保妇康栓在慢性宫颈炎合并人乳头瘤病毒(HPV)持续感染治疗中的效果。方法选取2019年10月至2020年10月该院收治的慢性宫颈炎合并HPV持续感染患者164例,随机分为研究组(82例)和对照组(82例),对照组于非月经期使用重组人干扰素α-2b阴道泡腾胶囊治疗,研究组于非月经期使用保妇康栓治疗,2组患者均持续治疗3个疗程。比较2组治疗后的HPV转阴率、治疗前后血清免疫球蛋白(Ig)水平、疗效及不良发应发生情况。结果研究组治疗后HPV转阴率高于对照组(P<0.05)。2组治疗前血清IgG、IgA、IgM水平差异无统计学意义(P>0.05);研究组治疗后血清IgG、IgA、IgM水平较治疗前均升高(P<0.05),且研究组高于对照组(P<0.05)。研究组的总有效率高于对照组(P<0.05)。2组治疗中均未发生严重不良反应(P>0.05)。结论保妇康栓治疗慢性宫颈炎合并HPV持续感染,可改善患者机体免疫状况,有助于患者HPV转阴,治疗效果明显且安全性较高,值得临床推广应用。

Objective To investigate the effect of Baofukang suppository in the treatment of chronic cervicitis complicated with persistent human papillomavirus(HPV).infection.Methods From October 2019 to October 2020,164 patients with chronic cervicitis complicated with HPV persistent infection in the hospital were selected and randomly divided into study group(82 cases)and control group(82 cases).The control group was treated with recombinant human interferonα-2b vaginal effervescent capsule during the non-menstrual period,and the study group was treated with Baofukang suppository during the non-menstrual period.The patients in both groups were treated for three courses.The HPV negative conversion rate after treatment,serum immunoglobulin(Ig)level before and after treatment,curative effect and adverse events were compared between the two groups.Results The HPV negative conversion rate in the study group was higher than that in the control group(P<0.05).There was no significant difference in serum IgG,IgA and IgM levels between the two groups before treatment(P>0.05).After treatment,the levels of serum IgG,IgA and IgM in the study group were significantly higher than those before treatment(P<0.05),and the study group was higher than that of the control group(P<0.05).The total effective rate of the study group was higher than that of the control group(P<0.05).There were no serious adverse reactions in both groups(P>0.05).Conclusion Baofukang suppository in the treatment of chronic cervicitis with persistent HPV infection can improve the immune status of patients and help patients turn HPV negative,with obvious therapeutic effect and high safety,which is worthy of clinical application.