0.03%他克莫司乳膏治疗儿童特应性皮炎的临床疗效观察

Observation on the clinical efficacy of 0.03% Tacrolimus emulsifiable pastein the treatment of children with atopic dermatitis

目的探讨0.03%他克莫司乳膏在儿童特应性皮炎的治疗中的临床疗效。方法选择2019年1月—2020年1月在本院门诊诊断为特应性皮炎的100例患儿作为研究对象,采用随机数表法平均分为治疗组和对照组两组,每组各50例。治疗组外用0.03%他克莫司乳膏于皮损处,对照组外用丁酸氢化可的松乳膏于皮损处,两组患儿同时服用左西替利嗪口服溶液,系统性治疗4周后,观察治疗效果及治疗结束后8周内的复发情况。结果治疗结束后,治疗组治疗有效率为88.0%,对照组为86.0%,两组治疗效果比较,差异无统计学意义(P>0.05)。治疗结束后4周内,治疗组复发率为2.0%,对照组复发率为12.0%,治疗组复发率低于对照组,差异有统计学意义(P<0.05)。结论 0.03%他克莫司乳膏在儿童特应性皮炎的治疗中具有良好的临床疗效,可以有效地预防疾病的反复发生。

Objective To observe the clinical efficacy of 0.03% tacrolimus cream in the treatment of children with atopic dermatitis.Methods A hundred of children diagnosis of atopic dermatitis in the screening in January 2019 to January 2020 in the outpatient were enrolled as study subjects, and they were divided into treatment group and control group according to random number table method, 50 cases in each group.0.03% tacrolimus cream was topically administrated at the skin lesions in the treatment group, and hydrocortisone butyrate cream was topical used at the skin lesions in the control group.Cetirizine was orally administrated in both two groups.After 4 weeks of systematically treatment, the therapeutic effect of the two groups were observed, and and recurrence within 8 weeks after treatment end was observed too.Results After the end of treatment, the effective rate of treatment was 88% in the treatment group and it was 86% in the control group.There was no significant difference in treatment effect between the two groups.Within four weeks after the end of treatment, the recurrence rate of the treatment group was 2% and that of the control group was 12%,and the recurrence rate of the treatment group was significantly lower than that of the control group( P < 0. 05).Conclusions 0. 03% tacrolimus cream has a good clinical effect in the treatment of children with atopic dermatitis,it could effectively prevent the recurrence of the disease.