谷红注射液联合血管内机械取栓治疗大动脉闭塞性脑梗死患者的临床观察

Clinical observation of Guhong injection combined with intravascular mechanical thrombus removal in the treatment of patients with large artery occlusive cerebral infarction

目的观察大动脉闭塞所致脑梗死患者应用谷红注射液联合机械取栓治疗的临床效果。方法选择2018年1月—2020年8月本院收治的106例急性脑梗死患者(大动脉闭塞性)作为研究对象,且所有患者均进行了血管内取栓治疗并成功恢复灌注,按机会均等的原则等比例分为对照组和治疗组两组,每组各53例。两组术后均按相关指南予标准化治疗,在此基础上,治疗组予谷红注射液,于不同时间节点观察两组患者的临床结局(NIHSS评分、mRS评分)、血液流变学相关指标及血管再通后闭塞的发生率。结果治疗组患者24 h、14 d、90 d的神经缺损情况(NIHSS评分、mRS评分)、血液流变学指标及作为取栓治疗并发症的血管再通后闭塞发生率治疗组均优于对照组(P<0.05)。结论大动脉闭塞所致的脑梗死患者在血管内机械取栓治疗开通责任血管后早期联合使用谷红注射液,可有效促进患者神经功能缺损的改善及降低血管内机械取栓治疗患者血管再通后闭塞的发生,值得推广。

Objective To observe the clinical effect of Guhong injection combined with mechanical thrombus removal in patients with cerebral infarction caused by aortic occlusion.Methods A total of 106 patients with acute cerebral infarction(aorta occlusive)who were hospitalized from January 2018 to August 2020 in our hospital were selected as study subjects,and received endovascular thrombus removal therapy to successfully restore perfusion.They were divided into control group(53 cases)and treatment group(53)according to the principle of equality of opportunity.Both groups were given standardized treatment according to relevant guidelines,and the study group was given Guhong injection on this basis.The clinical outcome of the two groups(NIHSS score,mRS score),hemorheology-related indicators and the incidence of occlusion after recanalization of the two groups of patients were observed at different time points.Results The 24 h,14 d,and 90 d neurological deficits(NIHSS score,mRS score),hemorheological indexes,and the incidence of occlusion after recanalization as a complication of thrombectomy therapy in the treatment group were better than those in the control group(P<0.05).Conclusions In patients with cerebral infarction caused by aortic occlusion,the early combined use of Guhong injection after mechanical thrombectomy therapy opens the responsible blood vessel could effectively promote the improvement of patients’neurological deficits and reduce the occlusion of patients after intravascular mechanical thrombectomy therapy,worth promoting.