儿童流行性腮腺炎患者SAA、CRP联合检测的意义

Significance of combined detection of SAA and CRP in children with epidemic parotitis

目的:探究血清淀粉样蛋白A(SAA)、C反应蛋白(CRP)及联合检测诊断儿童流行性腮腺炎的价值。方法:2019年6月-2021年3月收治儿童流行性腮腺炎患者75例,作为试验组;选取同期体检健康者75例,作为对照组。检测两组SAA、CRP指标水平,并分析数据正态性,比较两组阳性检出率;绘制ROC曲线分析SAA、CRP及联合检测诊断儿童流行性腮腺炎疾病的价值。结果:两组SAA、CRP检测数据均呈正态分布。试验组中7~9岁儿童患病率最高,且男性的患病率明显高于女性。试验组SAA及CRP水平均明显高于对照组,差异有统计学意义(P<0.05)。试验组SAA、CRP、SAA+CRP指标的阳性率均高于对照组。SAA、CRP、SAA+CRP诊断儿童流行性腮腺炎的ROC曲线下面积分别为0.938、0.852、0.97,差异均有统计学意义(P<0.05)。结论:SAA、CRP联合检测可用于诊断儿童流行性腮腺炎疾病,值得在临床上推广应用。

Objective:To explore the diagnostic value of serum amyloid A(SAA),C-reactive protein(CRP)and combined detection in children with epidemic parotitis.Methods:From June 2019 to March 2021,75 children with epidemic parotitis were selected as the experimental group.75 healthy people in the same period were selected as the control group.The levels of SAA and CRP in the two groups were detected,and the normality of the data was analyzed,we compared the positive rate between the two groups.ROC curve was drawn to analyze the diagnostic value of SAA,CRP and combined detection in children with epidemic parotitis.Results:SAA,CRP test data of the two groups were normal distribution.In the experimental group,the prevalence rate of children aged 7~9 was the highest,and the prevalence rate of men is significantly higher than that of women.The levels of SAA and CRP in the experimental group were significantly higher than those in the control group,the difference was statistically significant(P<0.05).The positive rates of SAA,CRP and SAA+CRP in the experimental group were higher than those in the control group.the difference was statistically significant(P<0.05).The area under the ROC curve of SAA,CRP and SAA+CRP in the diagnosis of mumps in children was 0.938,0.852 and 0.97 respectively,the difference was statistically significant(P<0.05).Conclusion:The combined detection of SAA and CRP can be used in the diagnosis of mumps in children,which is worthy of clinical application.