血清γ-谷氨酰转肽酶水平与2型糖尿病并发急性冠脉综合征的相关性探究

The correlation between serum gamma glutamyltranspeptidase level and type 2 diabetes mellitus complicated with acute coronary syndrome

目的探究血清γ-谷氨酰转肽酶水平(GGT)与2型糖尿病并发急性冠脉综合征(DA)的相关性。方法选取2018年1月1日至2019年12月31日沈阳辽中区近海济康医院收治的120例患者(其中,2型糖尿病并发急性冠脉综合征、2型糖尿病、急性冠脉综合征各40例)与40例来本院进行健康体检的体检者进行研究。将120例患者分为A组(2型糖尿病并发急性冠脉综合征)、B组(2型糖尿病)、C组(急性冠脉综合征),体检者为对照组,四组研究对象均进行血清指标检测,对比血清指标水平,分析GGT水平与DA的相关性。结果A组体质量均高于B组、C组及对照组,且GGT水平、糖化血红蛋白、低密度脂蛋白水平均高于B组、C组及对照组(P<0.05);A组胆固醇、甘油三酯高于对照组,而高密度脂蛋白水平低于对照组(P<0.05)。GGT与低密度脂蛋白水平、甘油三酯呈正相关性,P<0.05。结论当GGT水平上升,可影响2型糖尿病病情,增加急性冠脉综合征的发生率。因此,临床需要加大GGT的监测,及时了解是否并发急性冠脉综合征,为临床提供参考依据,保证患者安全性。

Objective:To explore the correlation between serum gamma glutamyltranspeptidase(GGT)level and type 2 diabetes mellitus complicated with acute coronary syndrome(DA).Methods:A total of 120 patients(including 40 patients with DA,40 patients with type 2 diabetes mellitus,40 patients with acute coronary syndrome),and 40 patients with physical examination in our hospital from January 1,2018 to December 31,2019 were selected as the research objects.120 patients were divided into group A(DA),group B(type 2 diabetes mellitus)and group C(acute coronary syndrome).The physical examinees were the control group.The serum indexes of the four groups were detected,and the correlation between GGT level and DA was analyzed.Results:The body weight of group A was higher than that of group B,group C and control group,and the levels of GGT,glycosylated hemoglobin and low-density lipoprotein were higher than those of group B,group C and control group(P<0.05);the levels of cholesterol and triglyceride in group A were higher than those in group B,group C and control group,while the level of high-density lipoprotein was lower than that of control group(P<0.05).GGT was positively correlated with low density lipoprotein and triglyceride(P<0.05).Conclusion:When the level of GGT rises,it can affect the condition of type 2 diabetes mellitus and increase the incidence of acute coronary syndrome.Therefore,the clinical need to increase the monitoring of GGT,timely understand whether complicated with acute coronary syndrome,to provide reference for clinical,to ensure the safety of patients.