摘要
目的探讨黄葵胶囊对糖尿病肾病患者肾小管损伤及氧化应激指标的影响。方法选取郑州大学第五附属医院收治的142例糖尿病肾病患者作为研究对象,按照随机数字表法分为观察组(71例)和对照组(71例)。对照组接受缬沙坦治疗,观察组接受黄葵胶囊联合缬沙坦治疗。观察两组疗效、肾小管损伤情况和氧化应激指标。结果观察组治疗总有效率(94.37%)高于对照组(83.10%),差异有统计学意义(P<0.05)。治疗后,两组患者尿α1-微球蛋白(α1-MG)、β2-微球蛋白(β2-MG)和视黄醇结合蛋白(RBP)水平降低,且观察组水平低于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者血清晚期氧化蛋白产物(AOPP)水平降低,超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)水平升高,且观察组AOPP水平低于对照组,SOD和GSH-Px水平高于对照组,差异均有统计学意义(P<0.05)。结论黄葵胶囊可减轻糖尿病肾病患者肾小管损伤程度,改善氧化应激水平。
Objective To explore the effects of Huangkui capsule on renal tubular injury and oxidative stress in patients with diabetic nephropathy.Methods A total of 142 patients with diabetic nephropathy admitted to the Fifth Affiliated Hospital of Zhengzhou University were selected as the subjects.They were divided into observation group(71 cases)and control group(71 cases)according to random number table.The control group was treated with valsartan,and the observation group was treated with Huangkui capsule combined with valsartan.The curative effect,renal tubular injury and oxidative stress were observed.Results The total effective rate of the observation group(94.37%)was higher than that of the control group(83.10%),the difference was statistically significant(P<0.05).After treatment,two groups of patients urineα1-microglobulin(α1-MG),β2-microglobulin(β2-MG)and urinary retinol binding protein(RBP)decreased,and the level in the observation group was lower than that in the control group(P<0.05).After treatment,the levels of serum advanced oxidized protein products(AOPP)decreased and the levels of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)increased in the two groups.The levels of AOPP in the observation group were lower than those in the control group,and the levels of SOD and GSH-Px were higher than those in the control group(P<0.05).Conclusion Huangkui capsule can reduce renal tubular injury and improve oxidative stress in patients with diabetic nephropathy.
作者
方一凡
FANG Yifan(Department of endocrinology,the Fifth Affiliated Hospital of Zhengzhou University,Zhenghou 450000,China)
出处
《河南医学研究》
CAS
2021年第26期4928-4930,共3页
Henan Medical Research
关键词
糖尿病肾病
黄葵胶囊
缬沙坦
肾小管损伤
氧化应激
diabetic nephropathy
Huangkui capsule
valsartan
renal tubular injury
oxidative stress