半夏白术天麻汤加味联合盐酸氟桂利嗪治疗椎-基底动脉供血不足所致眩晕症疗效观察

Curative effect of Banxia Baizhu Tianma Decoction combined with flunarizine hydrochloride in the treatment of vertigo caused by vertebrobasilar insufficiency

目的观察半夏白术天麻汤加味联合盐酸氟桂利嗪治疗椎-基底动脉供血不足所致眩晕症的临床疗效,并探讨其对患者症状积分及血液流变学的影响。方法回顾性分析2019年1月至2021年1月商洛市中医医院收治的86例椎-基底动脉供血不足所致眩晕症患者的临床资料,根据治疗方案分为对照组45例(予以盐酸氟桂利嗪治疗)和观察组41例(予以半夏白术天麻汤加味联合盐酸氟桂利嗪治疗)。两组患者均治疗两周,比较治疗效果、治疗前后的症状积分、血液流变学指标变化和不良反应发生情况。结果观察组患者的治疗总有效率为97.56%,明显高于对照组的84.44%,差异具有统计学意义(P<0.05);治疗后,两组患者的中医症候积分均明显下降,且观察组的头晕目眩、恶心呕吐、耳鸣或听力减退、倦怠乏力、汗出异常、发作频率中医症候积分明显低于对照组,差异均具有统计学意义(P<0.05);治疗后,两组患者的血液流变学各指标均有明显改善,且观察组患者的血浆黏度、全血黏度、纤维蛋白原、红细胞压积、血清D-二聚体等指标的改善程度明显大于对照组,差异均具有统计学意义(P<0.05);观察组和对照组患者的不良反应总发生率分别为9.76%,6.67%,差异无统计学意义(P>0.05)。结论半夏白术天麻汤加味联合盐酸氟桂利嗪治疗椎-基底动脉供血不足所致的眩晕症能显著缓解患者的临床症状,改善血液流变学指标,临床治疗效果显著且不良反应少。

Objective To observe the effect of Banxia Baizhu Tianma Decoction combined with flunarizine hy-drochloride in the treatment of vertigo caused by vertebrobasilar insufficiency,and to explore its effects on the patient's symptom score and hemorheology.Methods The clinical data of 86 patients with vertigo caused by vertebrobasilar in-sufficiency treated in Shangluo Hospital of Traditional Chinese Medicine from January 2019 to January 2021 were retro-spectively analyzed.According to the treatment plan,they were divided into the control group(45 cases,treated with flu-narizine hydrochloride)and the observation group(41 cases,treated with Banxia Baizhu Tianma Decoction combined with flunarizine hydrochloride).The patients in the two groups were treated for 2 weeks.The therapeutic effects,symp-tom scores before and after treatment,changes in hemorheological index,and the occurrence of adverse reactions be-tween the two groups were compared.Results The total effective rate of the observation group was 97.56%,which was significantly higher than 84.44%in the control group(P<0.05).After treatment,the scores of TCM syndromes in the two groups decreased significantly,and the scores of TCM syndrome in dizziness,nausea and vomiting,tinnitus or hearing loss,fatigue,abnormal sweating,and seizure frequency in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the indexes of hemorheology in the two groups significantly improved(P<0.05),and the improvement in the plasma viscosity,whole blood viscosity,fibrinogen,hematocrit,serum D-dimerization and other indicators of the observation group was significantly greater than that in the control group(P<0.05).The total incidence of adverse reactions in the observation group and the control group were 9.76%and 6.67%,respectively,and the difference was not statistically significant(P>0.05).Conclusion Banxia Baizhu Tianma Decoction combined with flunarizine hydrochloride in the treatment of vertigo caused by vertebrobasilar insufficiency can significantly alleviate the patient's clinical symptoms,improve hemorheology indicators,and have significant clinical treatment effects and few-er adverse reactions.