骨关节炎模型的研究进展

Research progress of osteoarthritis model

骨关节炎的发病机制尚不明确,目前的治疗方法仍不能有效阻止疾病进展。生物模型是研究疾病的重要工具,二维、三维细胞培养模型及生物反应器培养模型等体外模型,以及自发性、遗传修饰性、侵入性及非侵入性模型等动物体内模型,可模拟疾病的阶段性变化或发展全过程。对以上模型的研究是探索骨关节炎发生、发展过程的重要手段,亦是开发和评价治疗方法的重要依据。本文对骨关节炎模型及其特点进行综述,以期为骨关节炎的研究提供参考。

The mechanism of osteoarthritis is still not completely clear,the current treatment can not effectively prevent the disease from progressing.In order to study osteoarthritis,researchers have developed various models,including in vitro models(two-dimension and three-dimension cell culture models and bioreactor culture models)and in vivo models(spontaneous,genetically modified,invasive and non-invasive models).These models are important tools for studying the mechanism of disease occurrence and development,which can simulate the whole process or a certain stage of pathological changes,as well as evaluating the effect of treatment.This paper reviews the osteoarthritis models and their characteristics in order to provide reference for osteoarthritis research.