基于化疗的多模式联合抗肿瘤Janus纳米平台研究进展

Research progress in multi-modal combined anti-tumor Janusnano-platform based on chemotherapy

在癌症的治疗过程中,由于肿瘤的复杂性、多样性和异质性,大多数常规抗癌药物显示出狭窄的治疗窗.因此,目前临床研究的趋势已经逐渐从单一治疗转向选择具有不同治疗效果的双重药或多模式的联合疗法.Janus粒子可以独立控制不同药物的释放,减少各模式之间的相互干扰.本综述讨论了Janus纳米材料的制备方法和机理,评述了基于化疗的Janus纳米平台在多模式联合抗肿瘤领域的应用,提出了Janus纳米材料所面临的挑战.

In the process of cancer treatment,due to the complexity,diversity and heterogeneity of tumors,most conventional anticancer drugs show a narrow therapeutic window.Therefore,the current trend of clinical research has gradually shifted from a single treatment to a dual-drug or multi-modal combination therapy with different therapeutic effects.Janusparticles can independently control the release of different drugs,reducing mutual interference between modes.In this review,the preparation methods and mechanisms of Janusnanomaterials,the application of the Janusnanoplatform based on chemotherapy in the field of multi-mode combined anti-tumor applications,and the challenges faced by Janusnanomaterials are summarized.