MR高清扩散张量成像在甲状腺相关性眼病视神经病变的相关研究

The study of high-resolution diffusion tensor imaging in thyroid-associated ophthalmopathy

目的研究MR高清扩散张量成像技术在甲状腺相关性眼病(thyroid associated ophthalmopathy,TAO)患者早期视神经微结构损伤的应用。材料与方法收集临床确诊的无明显视神经病变的TAO患者及年龄与性别相匹配的健康志愿者(healthy controls,HC)各30例,分别进行眼眶常规MRI序列扫描及Resolve DTI序列扫描,分别测量双侧视神经的部分各向异性分数(fractional anisotropy,FA),表观扩散系数(apparent diffusion coefficient,ADC),轴向扩散率(axial diffusivity,AD),径向扩散率(radial diffusivity,RD)值,比较患者与健康志愿者之间双侧视神经各DTI相关定量参数值的差异。结果TAO患者的双侧视神经的FA值明显小于健康对照组(P=0.009,P=0.003;P<0.05),ADC及AD值差异无统计学意义(P=0.364,P=0.053,P=0.955,P=0.211;P>0.05),RD值高于正常对照组(P=0.010,P=0.009;P<0.05)。结论Resolve DTI技术有助于为TAO患者早期视神经微结构的损伤提供客观依据,对TAO患者视神经病变的治疗提供帮助。

Objective:To study the application of high-resolution MR diffusion readout-segmented of long variable echo-trains diffusion tensor imaging(Resolve DTI)in the early stage of optic nerve microstructure injury in patients with thyroid associated ophthalmopathy(TAO).Materials and Methods:Thirty TAO patients and 30 age and sex matched healthy controls(HC)were enrolled in this study.Conventional MRI and Resolve DTI sequences were used to scan the orbit respectively.FA,ADC,AD and RD values of bilateral optic nerves were measured.Quantitative parameters related to DTI of bilateral optic nerves were compared between patients and HC.Results:FA value of bilateral optic nerves in TAO patients was significantly lower than that of HC(P=0.009,P=0.003;P<0.05),ADC and AD value had no significant difference(P=0.364,P=0.053,P=0.955,P=0.211;P>0.05),and RD value was higher than that of HC(P=0.010,P=0.009;P<0.05).Conclusions:Resolve DTI imaging technology is helpful to provide objective basis for the damage of the early stage of optic nerve microstructure injury in TAO patients,and to provide help for the treatment of optic neuropathy in TAO patients.