化学交换饱和转移成像技术在肌肉骨骼系统的研究进展

Research progress of chemical exchange saturation transfer imaging technology in musculoskeletal system

化学交换饱和转移成像(chemical exchange saturation transfer,CEST)技术是一种新型磁共振成像技术,它可利用磁化传输比不对称(magnetization transfer ratio asymmetry,MTRasym)分析产生半定量的结果,对肌骨系统相关疾病的早期诊断和手术决策具有重要意义。传统MRI只能反映病变的形态学差异,很难为疾病的早期诊断提供帮助。CEST技术具有无侵入性和定量检测的优势,已应用于骨关节炎的早期诊断、椎间盘变性及软骨修复手术术后评估等。作者重点总结了CEST的原理、信号测定及其在肌肉骨骼系统的临床应用。

Chemical exchange saturation transfer imaging(CEST)is a new type of magnetic resonance imaging technology,which can produce semi-quantitative results using the magnetization transfer ratio asymmetry(MTRasym)analysis,which can provide early diagnosis of musculoskeletal system related diseases and surgical decisions are of great significance.Traditional MRI can only reflect the morphological differences of the lesion,and it is difficult to provide help for the early diagnosis of the disease.CEST technology realizes early diagnosis of osteoarthritis(OA),intervertebral discs degeneration,and post operative evaluation of cartilage repair surgery by detecting changes in metabolites in anatomical structures.This technology has the advantages of non-invasive and quantitative detection,and has been widely developed and applied in the central nervous system and musculoskeletal system.This article summarizes the concept,principle,signal measurement and clinical application in the musculoskeletal system of CEST.