细胞周期阻滞与脓毒症诱导的急性肾损伤研究进展

Research progress in the mechanism of cell cycle arrest in sepsis-induced acute kidney injury

脓毒症是ICU中病死率较高的一类疾病,其可以导致多器官功能障碍综合征(MODS),其中,脓毒症诱导的急性肾损伤(SAKI)发病率较高且与不良预后有关。目前对SAKI的发病机制缺乏全面的认识,这已成为其早期诊断和治疗的重要障碍。越来越多的研究证实,细胞周期阻滞作为一种肾脏的早期保护机制,是SAKI病理生理进程中的一项重要环节,可避免受损DNA的复制。本文总结细胞阻滞在SAKI中的作用机制,以及细胞周期阻滞的生物标志物,以期说明细胞周期阻滞可作为潜在治疗靶点,在早期预防或改善AKI预后中发挥作用。

Sepsis is a common syndrome with high mortality in ICU,which lead to MODS.Septic acute kidney injury(SAKI)has a high incidence and is associated with poor prognosis.The lack of comprehensive understanding of the pathogenesis of AKI is an important obstacle to its early diagnosis and treatment.However,more and more studies have confirmed that cell cycle arrest,as an early protective mechanism of the kidney,is a kind of important molecules mechanism and an important factor in the pathophysiological process in SAKI which can be treated as a target to avoid the replication of damaged DNA.We summarized the mechanism of cell cycle arrest in SAKI,as well as the markers of cell cycle block in this manuscript.We hope cell cycle block can be used as a potential therapeutic target for early prevention and improvement of prognosis of AKI.