脓毒症休克的诊治在精准医学时代下的发展及临床应用

Development and clinical application of the diagnosis and treatment of septic shock in the era of precision medicine

脓毒症休克病情凶险,致死率高。精准医学作为新型医学概念,其医疗模式影响了众多肿瘤及慢性病患者,也为脓毒症的精确诊治带来曙光。同时临床操作技术、基因检测、分子生物学的发展为脓毒症的精准诊治提供了数据和信息,通过对脓毒症患者不同病理生理状态、生物标志物、病原学、基因组学的分析与鉴定来进行个性化精准诊治。本文就精准医学在脓毒症休克诊治中取得的进展进行综述,并对这种新医疗模式的未来进行展望。

Septic shock is a critical condition with high mortality.Precision medicine as a new medical concept has affected cancer and chronic disease patients which also bring the hope for the accurate diagnosis and treatment in patients with sepsis.The development of clinical operation technology,gene detection and molecular biology provides data and information for the accurate diagnosis and treatment of sepsis,and promotes the progress and innovation of the diagnosis and treatment.Personalized and accurate management can be perfomed according to different pathophysiological status,biomarkers,etiology,genomics and other aspects.We review the progress of precision medicine in the diagnosis and treatment of sepsis,and prospects the future of this new medical model.