血必净联合血液净化对脓毒性休克患者血清APN、PCT、Lac水平的影响

Effects of Xuebijing combined with blood purification on serum APN, PCT and Lac levels in patients with septic shock

目的:分析血必净联合血液净化对脓毒性休克患者血清学指标和炎症水平的影响。方法:选取78例脓毒性休克患者,按照随机数字表法分为两组,每组各39例。两组均予以常规治疗,对照组加用血液净化治疗,观察组在对照组基础上予以血必净治疗。比较两组血清学指标、炎症水平和生命体征变化。结果:治疗后,观察组PCT、Lac均低于对照组,APN高于对照组,两组比较差异有统计学意义(P<0.05);治疗后,观察组TNF-α、IL-6水平均低于对照组,两组比较差异有统计学意义(P<0.05);治疗后,观察组MAP、OI均高于对照组,两组比较差异有统计学意义(P<0.05)。结论:血必净联合血液净化治疗可控制脓毒性休克患者体内炎症反应,加快PCT、Lac、APN水平复常,促使生命体征稳定。

Objective: To investigate the effects of Xuebijing combined with blood purification on the serum index and inflammation level of patients with septic shock. Methods: A total of 78 patients with septic shock were randomized into two groups, each with 39 cases. Both groups received conventional treatment. Then, the control group were treated with blood purification, while the observation group were treated with Xuebijing on the basis of the treatment for the control group. The serum indexes, inflammation levels and vital signs changes were compared between the two groups. Results: After treatment, PCT and Lac of the observation group was lower than that of the control group, and APN was higher than that of the control group, which were of statistical differences(P<0.05);the level of TNF-α and IL-6 in the observation group was lower than that of the control group after treatment, with statistical difference(P<0.05);MAP and OI of the observation group was higher than that of the control group, which was of statistical difference(P<0.05). Conclusion: Xuebijing combined with blood purification treatment can control the inflammatory response in patients with septic shock, accelerate PCT, Lac and APN levels to return to normal, and promote the stability of vital signs.