不同分期肺癌患者血清中PDCD5蛋白、CEA和CYFRA21-1表达水平变化及临床意义

Changes and Clinical Significance of PDCD5 Protein,CEA and CYFRA21-1 Expression in Different Stages of Lung Cancer

目的探讨不同分期肺癌患者血清中程序性细胞死亡分子5(PDCD5)蛋白、癌胚抗原(CEA)和细胞角蛋白19片段(CYFRA21-1)的表达水平变化及临床意义。方法选择89例原发性肺癌患者作为研究对象,采用酶联免疫吸附法测定其血清PDCD5蛋白水平,采用电化学发光免疫分析法检测血清CEA、CYFRA21-1水平。对比不同分期、不同肿瘤分化程度肺癌患者的血清中PDCD5蛋白、CEA和CYFRA21-1表达水平。结果不同T分期、N分期和分化程度肺癌患者的血清PDCD5、CEA、CYFRA21-1水平比较,差异有统计学意义(P<0.05)。肺癌患者T、N分期越高、分化程度越低,其血清PDCD5水平越低,血清CEA、CYFRA21-1水平越高,组间差异比较有统计学意义(P<0.05)。结论血清PDCD5蛋白、CEA和CYFRA21-1表达水平与肿瘤病理分期、分化程度有关,检测上述肿瘤标志物水平能够为肺癌患者的病理分期诊断提供重要参考,具有较高的临床应用价值。

Objective To research the expression of programmed cell death molecule 5(PDCD5),carcinoembryonic antigen(CEA)and cytokeratin 19 fragment(CYFRA21-1)in serum of patients with lung cancer at different stages and their clinical significance.Methods A total of 89 patients with primary lung cancer were selected as study subjects.The level of serum PDCD5 protein was determined by enzyme-linked immunosorbent assay,and the serum CEA and CYFRA21-1 levels were detected by electrochemiluminescence immunoassay.The expression levels of PDCD5 protein,CEA and CYFRA21-1 in serum of lung cancer patients with different stages and tumor differentiation degree were compared.Results The levels of PDCD5,CEA and CYFRA21-1 in patients with different T stage,N stage and differentiation degree were significantly different(P<0.05).The higher the T,N stage and the lower the differentiation degree,the lower the serum PDCD5 level,the higher the serum CEA and CYFRA21-1 levels,the differences between the groups were statistically significant(P<0.05).Conclusion The expression levels of PDCD5 protein,CEA and CYFRA21-1 were related to tumor pathological stage and differentiation degree.Detection of these tumor markers can provide important reference for pathological staging diagnosis of lung cancer patients,and has high clinical application value.