鼻咽癌病理组织中CXCR4表达与患者临床病理特征、新辅助化疗疗效及预后的关系

The Relationship between the Expression of CXCR4 in the Pathological Tissues of Nasopharyngeal Carcinoma and the Clinicopathological Characteristics,the Efficacy and Prognosis of Neoadjuvant Chemotherapy

目的探究鼻咽癌(NPC)病理组织中趋化因子受体4(CXCR4)表达与患者临床病理特征、新辅助化疗疗效及预后的关系。方法以97例NPC患者为研究对象,以其活检病理癌组织标本作为观察组(n=97),癌旁组织标本作为对照组(n=60)。比较癌组织及癌旁组织中CXCR4表达情况,并分析癌组织中CXCR4表达情况与患者临床病理特征、化疗疗效以及生存情况的关系。结果CXCR4在观察组中阳性表达率显著高于在对照组中的阳性表达率(46.39%vs.15.00%,P<0.05)。不同性别构成、年龄构成以及病理分型NPC患者癌组织中CXCR4阳性表达率与阴性表达率比较,差异无统计学意义(P>0.05);而TNM分期为Ⅲ期及Ⅳ期、淋巴结转移、化疗效果为疾病稳定(SD)以及疾病进展(PD)的NPC患者癌组织中的CXCR4阳性表达率显著高于阴性表达率(P<0.05)。癌组织中CXCR4表达阳性的鼻咽癌患者治疗后3年生存率、3年无进展生存率显著低于CXCR4表达阴性的鼻咽癌患者(57.78%vs.96.15%,40.00%vs.71.15%P<0.05)。结论NPC癌组织中CXCR4表达水平高于癌旁组织,且与患者临床病理特征、化疗效果及生存时间密切相关。

Objective To explore the relationship between the expression of chemokine receptor 4(CXCR4)in the pathological tissues of nasopharyngeal carcinoma(NPC)and the clinicopathological characteristics,the efficacy and prognosis of neoadjuvant chemotherapy.Methods 97 patients with NPC were selected the research object.The pathological cancer tissue specimens were used as the observation group(n=97)and the paracancerous tissue specimens as the control group(n=60).The expression of CXCR4 in cancer tissues and paracancerous tissues was compared,the relationships between the expression of CXCR4 in cancer tissues and clinicopathological features,chemotherapy efficacy and survival were analyzed.Results The positive expression rate of CXCR4 in the observation group was significantly higher than that of the control group(46.39%vs.15.00%,P<0.05).There were no significant differences in the positive expression rate and negative expression rate of CXCR4 between different sex composition,age composition and pathological classification of NPC patients(P>0.05).The positive expression rates of CXCR4 in cancer tissues of patients with TNM stageⅢand stageⅣ,lymph node metastasis,chemotherapy effect of stable disease(SD)and progressive disease(PD)were significantly higher than those of negative expression rate(P<0.05).The rates of 3-year survival and 3-year progression-free survival in the patients with NPC with positive expression of CXCR4 in the cancer tissues were significantly lower than those of the patients with NPC with negative expression of CXCR4(57.78%vs.96.15%,40.00%vs.71.15%,P<0.05).Conclusion The expression level of CXCR4 of cancer tissues is higher than that of paracancerous tissues in NPC patients,which is closely related to clinicopathological features,chemotherapy effect and survival time.