安宫牛黄丸联合西医对症治疗重症脑出血的疗效及对患者认知功能的影响

Curative Effect of Angong Niuhuang Pills Combined with Symptomatic Treatment of Western Medicine on Severe Cerebral Hemorrhage and Its Effect on Cognitive Function

目的:观察安宫牛黄丸联合西医对症治疗重症脑出血的疗效及对患者认知功能的影响。方法:选取90例重症脑出血患者,按随机数字表法分为治疗组与对照组各45例。对照组给予西医对症支持治疗,治疗组在对照组基础上给予安宫牛黄丸治疗。连续治疗2周后,评估2组临床疗效、中医证候积分、认知功能、神经功能缺损情况,并测定血清超敏C-反应蛋白(hs-CRP)、脑钠肽(BNP)变化水平。结果:治疗组总有效率为93.33%,高于对照组的71.11%(P<0.05)。与同组抢救成功后比较,药物治疗后2组中医证候积分、美国国立卫生研究院卒中量表(NIHSS)评分及血清hs-CRP、BNP水平均降低(P<0.05),简易精神状态表法(MMSE)评分升高(P<0.05);与对照组药物治疗后比较,治疗组药物治疗后中医证候积分、NIHSS评分及血清hs-CRP、BNP水平均较低(P<0.05),MMSE评分较高(P<0.05)。结论:安宫牛黄丸联合西医对症治疗重症脑出血疗效显著,可有效缓解患者临床症状,改善认知功能和神经功能,并能减轻炎症反应,降低BNP水平。

Objective:To observe the curative effect of Angong Niuhuang pills combined with symptomatic treatment of western medicine on severe cerebral hemorrhage and its effect on cognitive function. Methods: A total of 90 cases of patients with severe cerebral hemorrhage were selected and divided into the treatment group and the control group according to the random number table method,45 cases in each group. The control group was treated with symptomatic treatment of western medicine,and the treatment group was additionally treated with Angong Niuhuang pills based on the treatment of the control group. After two weeks of continuous treatment, the clinical effect, Chinese medicine syndrome score,cognitive function and neurological impairment in the two groups were evaluated,and the levels of serum high-sensitivity C-reactive protein(hs-CRP) and brain natriuretic peptide(BNP) were measured. Results:The total effective rate was 93.33%in the treatment group,higher than that of 71.11% in the control group(P<0.05). When compared with those in the same group after successful rescue, Chinese medicine syndrome score, scores of National Institutes of Health Stroke Scale(NIHSS),as well as levels of hs-CRP and BNP in serum in the two groups were decreased after medication(P<0.05),and the scores of Mini-Mental State Examination(MMSE) were increased(P<0.05). After medication, Chinese medicine syndrome score,NIHSS score,as well as levels of hs-CRP and BNP in serum in the treatment group were lower than those in the control group(P<0.05),and the MMSE score was higher(P<0.05). Conclusion:The therapy of Angong Niuhuang pills combined with symptomatic treatment of western medicine has a significant curative effect on severe cerebral hemorrhage,which can effectively relieve clinical symptoms,improve cognitive function and neurological function,alleviate inflammatory responses,and reduce BNP level.