扶正抗癌汤联合FOLFOX4方案治疗进展期胃癌术后临床观察

Clinical Observation of Fuzheng Kang’ai Tang Combined with FOLFOX4 Scheme in Treatment of Advanced Gastric Cancer After Surgery

目的:观察扶正抗癌汤联合FOLFOX4方案化疗对进展期胃癌术后的临床疗效。方法:回顾性分析102例进展期胃癌术后患者,按照治疗方式不同分为观察组及对照组,观察组给予扶正抗癌汤联合FOLFOX4方案治疗,对照组仅应用FOLFOX4方案治疗。14 d为1个周期,2组均治疗2个周期。观察2个周期后2组临床疗效及不良反应,比较2组治疗前后生活质量[卡氏行为状态评分表(KPS)、生活质量核心量表(QLQ-C30)]。结果:治疗后,观察组疾病客观缓解率(ORR)为63.46%,高于对照组36.00%(P<0.05);观察组临床获益率(CBR)为88.46%,高于对照组52.00%(P<0.05)。治疗期间,观察组骨髓抑制现象、消化道反应及周围神经毒性方面发生率均低于对照组,差异均有统计学意义(P<0.05)。在肝、肾功能损害方面,差异均无统计学意义(P>0.05)。治疗后,2组KPS评分及QLQ-C30评分均较治疗前升高(P<0.05),观察组2项评分均高于对照组(P<0.05)。结论:扶正抗癌汤联合FOLFOX4方案治疗胃癌术后,能提高临床疗效,减轻不良反应发生率,有效改善患者的生活质量,改善预后。

Objective: To observe the clinical effect of Fuzheng Kang’ai tang combined with FOLFOX4 scheme in the treatment of advanced gastric cancer after surgery. Methods:A total of 102 cases of patients with advanced gastric cancer after surgery were retrospectively analyzed. According to different treatment methods, they were divided into the observation group and the control group. The observation group was treated with Fuzheng Kang’ai tang combined with FOLFOX4 scheme, while the control group was only treated with FOLFOX4 scheme. Both groups were treated for two cycles. After two cycles, clinical effect in the two groups was observed. Adverse reactions and quality of life [Karnofsky Performance Status(KPS), Quality of Life Questionnaire-Core 30(QLQ-C30)] were compared between the two groups.Results:After treatment,objective remission rate(ORR) was 63.46% in the observation group,higher than that of 36.00%in the control group(P<0.05);clinical benefit rate(CBR) was 88.46% in the observation group,higher than that of 52.00% in the control group(P<0.05). During treatment,the incidences of myelosuppression,gastrointestinal reactions and peripheral neurotoxicity in the observation group were lower than those in the control group, differences being significant(P<0.05).There was no significant difference being found in the comparison of the liver and kidney dysfunction(P>0.05). After treatment,scores of KPS and QLQ-C30 in the two groups were increased when compared with those before treatment(P<0.05),and the two scores in the observation group were higher than those in the control group(P<0.05). Conclusion:The therapy of Fuzheng Kang’ai tang combined with FOLFOX4 scheme in the treatment of advanced gastric cancer after surgery can enhance the clinical effect,reduce the incidence of adverse reactions,effectively improve quality of life,and improve prognosis.