肿瘤坏死因子α刺激基因/诱导蛋白-6的抗炎作用研究进展

Research progress on the anti-inflammatory effect of tumor necrosis factor alpha stimulated gene/inducible protein 6

炎症损伤是众多临床疾病的病理学基础,常可引起严重并发症甚至导致死亡。然而传统临床治疗不仅方法有限,且效果不佳。近年研究报道,肿瘤坏死因子α刺激基因/诱导蛋白-6(tumor necrosis factor alpha stimulated gene/inducible protein 6,TSG-6)可通过与体内相应的配体结合参与炎症反应的多个过程,并发挥抗炎和促进细胞外基质重塑等重要作用。本文就TSG-6的生物学特性、作用机制及其在病理性瘢痕、神经炎症、动脉粥样硬化和关节炎等多种疾病中发挥的抗炎作用作一综述。

Inflammatory injury is a key pathological factor for many clinical diseases,which can often cause serious complications or death.However,traditional clinical methods are rare and with limited therapeutic effects.Recent studies show that tumor necrosis factor alpha stimulated gene inducible protein 6(TSG-6)can participate in many inflammatory processes through its association with different ligands in vivo,and play an important role in anti-inflammatory and promoting extracellular matrix remodeling.In this review,we focus mainly on the basic biological characteristics and mechanism of TSG-6,and summarize its anti-inflammatory effects in pathologic scars,neuroinflammation,atherosclerosis and joint inflammation.