氧化苦参碱的肾脏保护作用及其机制的研究进展

Research progress on renal protection and its mechanism of oxymatrine

氧化苦参碱具有抗肾缺血再灌注损伤、抗内毒素性肾损伤、抗四氯化碳致慢性肾损伤、抗阿霉素肾病、抗输尿管梗阻大鼠肾间质纤维化和抗高糖、高脂诱导的肾脏纤维化的作用。氧化苦参碱肾脏保护作用的作用机制是抗氧化、抗炎、降血糖、调血脂作用,抑制活性氧(ROS)/TLR4、PERK/ATF4/CHOP、JAK2/STATs、TGF-β1/Smads和NF-κB/TNF-α信号通路,减轻肾损伤炎症反应和细胞外基质沉积,阻滞肾损伤和纤维化。

Oxymatrine has antagonisms to kidney ischemia/reperfusion injury,endotoxic renal injury,CCl4-inguced chronic renal injury,adriamycin nephrosis,renal interstitial fibrosis after ureteral obstruction in rat,and renal fibrosis induced by high glucose and high fat.Its mechanisms of renal protection are antioxidation,anti-inflammation,hypoglycemia,and hypolipemia of oxymatrine,and inhibiting signaling pathways of ROS/TLR4,PERK/ATF4/CHOP,JAK2/STATs,TGF-β1/Smads,and NF-κB/TNF-α,to alleviate renal tissue inflammation and extracellular matrix deposit,and block renal injury and fibrogenesis.