P/Q型电压门控钙离子通道抗体阳性的Lambert-Eaton肌无力综合征临床特征分析

Clinical characteristics of Lambert-Eaton myasthenic syndrome with positive P/Q-type voltage-gated calcium channel antibody

回顾性分析2016年6月至2018年1月北京协和医院神经科的18例Lambert-Eaton肌无力综合征(LEMS)患者的临床资料并应用放射免疫沉淀法检测其P/Q型电压门控钙离子通道(VGCC)抗体。抗体阳性率15/18,抗体阳性和阴性组性别、年龄、病情严重程度、肿瘤患病率比较差异均无统计学意义。抗体阳性组病程较短(1.9年比7.6年,P=0.04),高VGCC抗体滴度的临床表现更丰富,抗体滴度与复发具有显著相关性(τ=0.48,P=0.02)。

The clinical data of 18 patients diagnosed with Lambert-Eaton myasthenic syndrome(LEMS)from Department of Neurology of Peking Union Medical College Hospital from June 2016 to January 2018 were retrospectively analyzed and P/Q-type voltage-gated calcium channel(VGCC)antibodies were detected by radioimmunoprecipitation assay.The VGCC antibody(Ab)-positive rate of LEMS was 15/18,and there were no significant differences in gender,age,disease severity,and tumor prevalence.The disease course was shorter in the antibody-positive group(1.9 years vs 7.6 years,P=0.04),and the clinical manifestation was more complicated in the group with a higher VGCC-Ab.There was a significant correlation between VGCC-Ab and recurrence rate(τ=0.48,P=0.02).