黄葵胶囊联合缬沙坦对糖尿病肾病患者肾功能及HIF-1α、VEGF水平的影响

Effects of Huangkui capsule combined with valsartan on renal function,HIF-1αand VEGF levels in diabetic nephropathy patients

目的探讨黄葵胶囊联合缬沙坦对糖尿病肾病(DN)患者肾功能及缺氧诱导因子-1α(HIF-1α)、血管内皮生长因子(VEGF)水平的影响。方法回顾性分析2018年1月至2020年2月本院收治的80例糖尿病肾病患者的临床资料,根据治疗方法的不同分为两组,每组40例。对照组采用缬沙坦治疗,观察组在对照组基础上联合黄葵胶囊治疗。比较两组治疗前后肾功能[血尿素氮(BUN)、血肌酐(SCr)、β_(2)微球蛋白(β_(2)-MG)以及尿白蛋白排泄率(UAER)]、HIF-1α和VEGF水平及中医证候积分[易饥多食、口干欲饮、心烦失眠、便秘、尿频]。结果治疗后,两组BUN、SCr、β_(2)-MG以及UAER水平均低于治疗前,差异有统计学意义(P<0.05);治疗后,观察组BUN、SCr、β_(2)-MG及UAER水平均低于对照组,差异有统计学意义(P<0.05);治疗后,两组HIF-1α及VEGF水平均低于治疗前,差异有统计学意义(P<0.05),且观察组均低于对照组,差异有统计学意义(P<0.05);治疗后,两组易饥多食、口干欲饮、心烦失眠、便秘及尿频证候评分均低于治疗前,差异有统计学意义(P<0.05),且观察组均低于对照组,差异有统计学意义(P<0.05)。结论黄葵胶囊联合缬沙坦治疗糖尿病肾病效果显著,可减轻患者肾功能损伤,降低HIF-1α、VEGF水平,改善临床症状,值得临床推广运用。

Objective To investigate the effects of Huangkui capsule combined with valsartan on renal function,hypoxia-inducing factor-1α(HIF-1α)and vascular endothelial growth factor(VEGF)levels in patients with diabetic nephropathy(DN).Methods The clinical data of 80 patients with diabetic nephropathy admitted to our hospital from January 2018 to February 2020 were retrospectively analyzed.According to the different treat-ment methods,they were divided into two groups,with 40 cases in each group.The control group was treated with valsartan and the observation group was treated with Huangkui capsule on the basis of the control group.Renal function[blood urea nitrogen(BUN),blood creatinine(SCr),β_(2)microglob ulin(β_(2)-MG)and urinary albumin excretion rate(UAER)],HIF-1αand VEGF levels and TCM syndrome score[easy hunger and need more food,dry mouth and desire to drink,restlessness and insomnia,constipation,frequency of urination]were compared between two groups before and after treat-ment.Results After treatment,BUN,SCr,β_(2)-MG and UAER levels in two groups were lower than before treatment,the differences were statistically significant(P<0.05);after treatment,the levels of BUN,SCr,β_(2)-MG and UAER in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05);after treatment,the levels of HIF-1αand VEGF in two groups were lower than before treat-ment,the difference was statistically significant(P<0.05),and the observation group was lower than the control group,the difference was statistically significant(P<0.05);after treatment,the scores of syndromes of easy hunger and need more food,dry mouth and desire to drink,restlessness and in-somnia,constipation,frequency of urination in two groups were lower than before treatment,and the difference was statistically significant(P<0.05),and the observation group was lower than the control group,the difference was statistically significant(P<0.05).Conclusion Huangkui cap-sule combined with valsartan has significant effect in the treatment of diabetic nephropathy,which can reduce renal function injury,reduce HIF-1αand VEGF levels,and improve clinical symptoms.It is worthy of clinical application.