rhBNP联合多巴胺治疗老年心肾综合征的疗效观察

Observation of the efficacy of rhBNP combined with dopamine in the treatment of elderly heart and kidney syndrome

目的探讨重组人脑利钠肽(rhBNP)联合多巴胺治疗老年心肾综合征的疗效。方法选取2017年3月至2019年12月于本院ICU接受治疗的110例老年心肾综合征患者,随机分为观察组和对照组,各55例。对照组给予强心利尿等常规治疗,观察组在对照组基础上联合rhBNP和多巴胺治疗。比较两组临床疗效、心肾功能指标及不良反应发生率。结果观察组临床总有效率高于对照组,差异有统计学意义(P<0.05);治疗1周后,两组NT-proBNP、SCr、BUN水平均低于治疗前,LVEF水平高于治疗前,且观察组均优于对照组,差异有统计学意义(P<0.05);治疗1周后,两组CI、DPmx水平均高于治疗前,GEDI、ELWI水平低于治疗前,且观察组均优于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较差异无统计学意义。结论rhBNP联合多巴胺治疗老年心肾综合征疗效确切,可改善心肾功能,且安全性较高,值得临床推广应用。

Objective To investigate the efficacy of recombinant human brain natriuretic peptide(rhBNP)combined with dopamine in the treat-ment of elderly heart and kidney syndrome.Methods 110 elderly patients with cardiorenal syndrome treated in our hospital from March 2017 to De-cember 2019 were randomly divided into observation group and control group,with 30 cases in each group.The control group was given convention-al treatments such as cardiac diuresis.The observation group was treated with rhBNP and dopamine on the basis of the control group.The clinical ef-ficacy,cardio-renal function index,and incidence of adverse reactions were compared between the two groups.Results The total effective rate in the observation group was higher the control group,and the difference was statistically significant(P<0.05).After 1 week of treatment,the levels of NT-proBNP,SCr,and BUN in the two groups were lower than before treatment,and the LVEF levels were lower than before treatment,and the obser-vation group was better than the control group,the difference was statistically significant(P<0.05).After 1 week of treatment,the levels of CI and DPmx in the two groups were higher than before treatment,and the levels of GEDI and ELWI were lower than before treatment,and the observation group was better than the control group,the difference was statistically significant(P<0.05);the incidence of adverse reactions was not significantly different between the two groups.Conclusion rhBNP combined with dopamine is effective in the treatment of senile heart and kidney syndrome.It can improve the heart and kidney function and has high safety.It is worthy of clinical application.