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SIRT6在骨代谢中的作用研究进展

Recent advances made with SIRT6 and its implications in bone metabolism
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摘要 Sirtuin6(SIRT6)属于Sirtuin家族,具有去乙酰化酶和ADP-核糖基转移酶活性,在骨代谢、基因稳定、葡萄糖代谢、脂质代谢、炎性介质调控、肿瘤发生中发挥关键作用。本综述主要总结了SIRT6在骨代谢中的作用及其相关的分子信号通路。
作者 王小同 杜娟 WANG Xiaotong;DU Juan
出处 《口腔生物医学》 2021年第2期132-135,共4页 Oral Biomedicine
基金 国家自然科学基金(81873706) 北京市卫生系统高层次人才(2014-3-077)。
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  • 1Sims NA, Martin TJ. Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit. Bonekey Rep 2014; 3: 481.
  • 2Shuler FD, Conjeski J, Kendall D et aL Understanding the burden of osteoporosis and use of the World Health Organization FRAX. Orthopedics 2012; 35(9): 798~805.
  • 3Mostoslavsky R, Chua KF, Lombard DB et aL Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 2006; 124(2): 315-329.
  • 4Feng X, McDonald JM. Disorders of bone remodeling. Annu Rev Pathol Mech Dis 2011; 6(1): 121-145.
  • 5Lombard DB, Schwer B, AIt FW et aL SIRT6 in DNA repair, metabolism and ageing. J Intern Med 2008; 263(2): 128-141.
  • 6Sims NA, Gooi JH. Bone remodeling: multiple cellular interactions required for coupling of bone formation and resorption. Semin Cell Dev Bio12008; 19(5): 444451.
  • 7Kawahara TL, Michishita E, Adler AS etaL SIRT6 links histone H3 lysine 9 deacetyla- tion to NF-i~B~tependent gene expression and organismal life span. Ce112009; 136(1): 62-74.
  • 8Kim HS, Xiao C, Wang RH et al. Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab 2010; 12(3): 224-236.
  • 9Zhong L, D'Urso A, Toiber D et al. The histone deacetylase Sirt6 regulates glucose homeostasis via Hiflalpha. Cell 2010; 140(2): 280-293.
  • 10Sebasti~,n C, Zwaans BM, Silberman DM eta/. The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell 2012; 151(6): 1185-1199.

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