宫颈癌患者中血清糖类抗原125 IL-6鳞状细胞癌抗原表达的临床意义

The Clinical Significance of Serum Carbohydrate Antigen 125 IL-6 and Squamous Cell Carcinoma Antigen Expression in Patients with Cervical Cancer

目的:观察宫颈癌患者、子宫肌瘤患者及健康对照者血清中的糖类抗原125(CA125)、白细胞介素-6(IL-6)、鳞状细胞癌抗原(SCCA)的表达水平。方法:收集并测定96例子宫颈癌患者、64例子宫肌瘤患者及72例健康对照者血CA125、IL-6、SCCA的浓度,并分析血清中CA125、IL-6、SCCA的表达水平的临床价值。结果:3组血清中CA125、IL-6、SCCA的表达水平存在差异(P<0.05),宫颈癌血清中CA125、IL-6、SCCA水平最高(P<0.05),健康对照组血清中CA125、IL-6、SCCA水平最低(P<0.05)。高分化、中分化、低分化的宫颈癌患者,其血清中CA125、IL-6、SCCA的表达水平也不尽相同(P<0.05),低分化宫颈癌患者血清中CA125、IL-6、SCCA水平最高(P<0.05),高分化宫颈癌患者血清中CA125、IL-6、SCCA水平最低(P<0.05)。宫颈癌患者中不同病理分期血清中CA125、IL-6、SCCA水平存在差异(P<0.05),IV期宫颈癌患者血清中CA125、IL-6、SCCA水平最高(P<0.05)。宫颈癌患者血清中IL-6的浓度水平与患者的年龄无显著的相关性(r=0.096,P>0.05),肿瘤的大小与血清中IL-6的浓度水平呈现正相关(r=0.697,P<0.05)。宫颈癌患者血清中CA125、SCCA与年龄和肿瘤大小均呈现正相关(P<0.05)。结论:在宫颈癌的诱发、分化以及发展进程中,CA125、IL-6、SCCA的起到了十分重要的作用,通过对患者血清中上述三者的表达水平进行检测,可能有助于判断和分析宫颈癌患者的肿瘤特性、病情监测等过程中。

Objective:To observe the expression levels of glucose antigen 125(CA125),interleukin-6(IL-6)and squamous cell carcinoma antigen(SCCA)in serum of patients with cervical cancer,uterine fibroids and healthy controls.Methods:Serum CA125,IL-6 and SCCA levels were detected in 96 patients with cervical cancer,64 patients with uterine fibroids and 72 healthy controls,and the clinical significance of serum CA125,IL-6 and SCCA expression levels were analyzed.Results:There were significant differences in the expression levels of serum CA125,IL-6 and SCCA among the three groups(P<0.05).The serum levels of CA125,IL-6 and SCCA in cervical cancer patients were the highest(P<0.05).The serum levels of CA125 and IL were the highest in healthy control group(P<0.05).SCCA level was the lowest(P<0.05).The expression levels of CA125,IL-6 and SCCA in serum of highly differentiated,moderately differentiated and poorly differentiated cervical cancer patients were also different(P<0.05).The serum levels of CA125,IL-6 and SCCA in patients with low differentiation of cervical cancer were the highest(P<0.05),and the serum levels of CA125,IL-6 and SCCA in patients with high differentiation of cervical cancer were the lowest(P<0.05).There were significant differences in serum CA125,IL-6 and SCCA levels among cervical cancer patients with different pathological stages(P<0.05).The serum levels of CA125,IL-6 and SCCA in stageⅣcervical cancer patients were the highest(P<0.05).There was no significant correlation between serum IL-6 concentration and age of patients with cervical cancer(r=0.096,P>0.05),but there was a positive correlation between tumor size and IL-6 concentration(r=0.697,P<0.05).Serum CA125 and SCCA were positively correlated with age and tumor size in patients with cervical cancer(P<0.05).Conclusion:CA125,IL-6 and SCCA play an important role in the induction,differentiation and development of cervical cancer.Detection of the expression levels of the above three genes in the serum of patients is helpful to judge and analyze the cervix in the process of monitoring the tumor characteristics and disease of patients.