碳青霉烯类耐药肠杆菌科细菌实验室检测的研究

Detection Method for Carbapenem-Resistant Enterobacteriaceae

目前碳青霉烯类耐药肠杆菌科细菌(CRE)在世界各地已呈广泛流行的趋势,特别是碳青霉烯酶的扩散严重威胁着公共健康。临床微生物实验室如何选择适合的检测方法,从而出具及时准确的报告对于防控耐药菌株的传播以及指导临床医生用药具有重要的价值。本文就耐药机制及表型、基因型以及酶免疫层析技术三大类CRE检测方法进行综述。

At present,carbapenem-resistant enterobacteriaceae(CRE)has been widely prevalent all over the world.In particular,the spread of carbapenemase is a serious threat to public health.How to choose suitable detection methods for clinical microbiology laboratories to give the report timely and accurately is valuable for preventing and controlling the spread of drug-resistant strains,guiding clinicians in medication.This article reviews the three types of CRE detection methods including phenotype,genotype and enzyme immunochromatography.