离子液体[C_(14)mim]BF_(4)对大鼠的急性毒性

Acute toxicity of ionic liquids [C_(14)mim]BF_(4) to rats

为探究离子液体(ionic liquids,ILs)对哺乳动物的毒性作用,文章采用经济合作与发展组织(Organization for Economic Co-operation and Development,OECD)的“up-and-down procedure”(UDP),研究了四氟硼酸化1-十四烷基-3-甲基咪唑盐([C_(14)mim]BF_(4))对大鼠的急性毒性,并采用HE染色法观察了其对大鼠肝、肾、胃等脏器组织的损伤。结果表明,[C_(14)mim]BF_(4)对大鼠的肝、肾等脏器均有损伤,其半数致死量(LD _(50))为249.8 mg/kg,属于中等毒性。研究结果为咪唑型ILs毒性作用的探究提供了实验参考依据。

In order to explore the toxicity of ionic liquids(ILs)to mammals,the up-and-down procedure(UDP)revised by Organization for Economic Co-operation and Development(OECD)was adopted to evaluate the acute toxicity of ILs tetrafluoroborate1-tetradecyl-3-methyl imidazole salt([C_(14)mim]BF_(4))to rats.The damage of ILs to liver,kidney,stomach and other organs in rats was observed by hematoxylin-eosin(HE)staining.The results showed that[C_(14)mim]BF_(4) had damage to liver,kidney and other organs in rats and its median lethal dose(LD_(50))was 249.8 mg/kg,which was moderately toxic.These results provide reference for the study of the toxicity of imidazole ILs.