经颅电刺激在啮齿动物中的研究进展

Research progress of transcranial electrical stimulation in rodents

经颅电刺激(transcranial electrical stimulation,tES)是一种通过在头皮上施加微弱电流来改变大脑功能的神经调节工具。该方法在上世纪80年代被提出,随着社会老龄化和神经系统疾病发病率的日益增长,该方法由于其无创、副作用小、成本低、易操作等优势,近年来逐渐受到重视[1]。目前tES已应用于改善认知功能和运动功能障碍,以及治疗包括阿尔茨海默病(Alzheimer disease,AD)和帕金森病(Parkinson disease,PD)在内的神经退行性疾病。

Transcranial electrical stimulation(tES)regulates the activity of neurons in the brain by applying a specific pattern of weak electricity.tES is widely used in neurological diseases,such as Alzheimer disease,Parkinson disease and stroke,and in the improvement of cognition and behavior.Rodent model is an indispensable tool in basic medicine and pre-clinical researches,and tES has great advantages in the application of this model.This review mainly discusses the stimulatory effect and mechanism of tES in rodent models,and summarizes the stimulation parameters of tES.