基于α, β-不饱和酮的膦氢化反应创新实验

Innovative experiment of phosphine hydrogenation based onα,β-unsaturated ketone

科学研究与实验教学紧密结合对培养创新型人才具有十分重要的意义。为了培养学生的学习能力、创新能力和独立科研的能力,将部分科研成果转化为一项创新实验。含膦化合物是过渡金属催化反应中常用的一类配体,手性含膦化合物也可以作为不对称催化的有机催化剂。根据Claisen-Schmidt缩合反应首先制备得到α,β-不饱和酮类反应底物,随后使用具备强Lewis酸性的非金属催化剂三(五氟苯基)硼烷B(C_(6)F_(5))_(3),催化实现了α,β-不饱和酮类底物的非手性膦氢化反应,取得了较好的收率。

The close integration of scientific research and experimental teaching is of great significance for cultivating innovative talents.In order to cultivate students’learning ability,innovation ability and independent research ability,we transform some scientific research results into an innovative experiment.Phosphorus compounds are widely useful ligands for transition-metals in catalysis and chiral phosphorus compounds they are capable of acting as organocatalysts for asymmetric reactions.Theα,β-unsaturated ketones were first prepared according to the Claisen-Schmidt condensation reaction.Non-metallic trifluorophenyl borane B(C_(6)F_(5))_(3),a strong Lewis acid catalyst,was then used to catalyze the achiral phosphine hydrogenation ofα,β-unsaturated ketone substrates with good yields.