重度子痫前期产妇发生母婴不良结局的相关危险因素分析

Analysis of related risk factors of adverse maternal and infant outcomes in parturient with severe preeclampsia

目的:探讨重度子痫前期产妇发生母婴不良结局的相关危险因素。方法:回顾性分析2018年2月至2020年5月我院收治的189例重度子痫前期产妇临床资料,按照妊娠结局不同分为母婴不良结局组84例和无母婴不良结局组105例,分析重度子痫前期产妇发生母婴不良结局的相关危险因素。结果:母婴不良结局组年龄≥35岁、合并妊娠期糖尿病(GDM)、产次<1次、多胎、发病孕周<34周比例高于无母婴不良结局组(P<0.05);2组孕次、既往有子痫前期病史、高血压家族史、孕前体重指数(BMI)、合并妊娠期肝内胆汁淤积症(ICP)相比,差异无统计学意义(P>0.05);多因素Logistic回归分析显示,年龄≥35岁、合并GDM、产次<1次、多胎、发病孕周<34周是重度子痫前期产妇发生母婴不良结局的独立危险因素(P<0.05且OR>1)。结论:高龄、多胎、初产妇、发病早、合并GDM是重度子痫前期产妇发生母婴不良结局的高危因素,临床需加强防治。

Objective:To explore the related risk factors of adverse maternal and infant outcomes in parturient with severe preeclampsia.Methods:The clinical data of 189 parturients with severe preeclampsia admitted to our hospital from Feb 2018 to May 2020 were retrospectively analyzed.According to the different pregnancy outcomes,they were divided into an adverse outcome group of 84 cases and a non-adverse outcome group of 105 cases.The related risk factors of adverse maternal and infant outcomes were analyzed.Results:The proportions of age≥35 years old,complicated with gestational diabetes(GDM),parity<1,multiple births,and gestational age<34 weeks in the adverse outcome group were higher than those of the non-adverse outcome group(P<0.05).There was no statistically significant difference in the number of pregnancy,history of previous preeclampsia,family history of hypertension,pre-pregnancy body mass index(BMI),and intrahepatic cholestasis of pregnancy(ICP)in the two groups(P>0.05).Multivariable logistic regression analysis showed that age≥35 years old,combined with GDM,parity<1,multiple births,gestational week<34 weeks were independent risk factors for adverse maternal and infant outcomes(P<0.05 and OR>1).Conclusion:Advanced age,multiple births,primipara,early onset,and GDM are high-risk factors for the adverse maternal and infant outcomes in parturient with severe preeclampsia.