新型杀菌剂苯并烯氟菌唑合成研究

Study on the synthesis of new fungicide benzovindiflupyr

研究了一种简便、温和、高效的苯并烯氟菌唑合成方法,以医药中间体2-氨基-6-硝基苯甲酸为起始原料,经环加成、烯烃化、加氢还原、缩合4步反应合成了苯并烯氟菌唑。总收率57%以上,含量98%以上,并通过液相色谱、核磁氢谱等分析手段确认了关键中间体及苯并烯氟菌唑结构。该工艺路线更加清洁、高效、可行,具有较好的工业化应用前景。

A simple,mild and efficient method for the synthesis of benzovindiflupyr was studied.Benzovindiflupyr was synthesized by cycloaddition,alkylation,hydrogenation reduction and condensation from 2-amino-6-nitrobenzoic acid as the starting material.The total yield was over 57%and the content was over 98%.The structure of key intermediates and benzovindiflupyr were confirmed by HPLC and 1H NMR.The process is cleaner,more efficient and feasible,and has a good prospect of industrial application.