lncRNA-FTX与脑胶质瘤病人预后的相关性分析

Correlation between lncRNA FTX level in glioma tissues and survival prognosis of patients with glioma

目的探讨长链非编码RNA(lncRNA)FTX表达水平与脑胶质瘤病人预后的相关性。方法前瞻性收集2016年1月~2018年1月手术切除的脑胶质瘤88例(46例获得瘤旁组织),采用实时逆转录PCR检测lncRNA FTX表达水平,以脑胶质瘤组织lncRNA FTX表达水平均值为界分为高表达组(n=57)和低表达组(n=31)。术后随访3年,主要观察指标为无进展生存期、总生存期。结果脑胶质瘤组织lncRNA FTX表达水平[(7.54±2.15)]明显高于瘤旁组织[(2.65±0.69);P<0.001]。多因素Cox比例回归风险模型分析显示,lncRNA FTX高表达是脑胶质瘤生存预后不良的独立危险因素(RR=1.589;95%CI 1.004~2.515;P=0.048)。生存曲线分析显示,高表达组无进展生存期(15.10个月)和总生存期(20.24个月)较低表达组(分别为18.96和25.53个月)明显缩短(P<0.05)。结论脑胶质瘤lncRNA FTX呈高表达,与病人不良生存预后有关。

Objective To explore the correlation between the expression level of long non-coding RNA(lncRNA)FTX in glioma tissues and the survival prognosis of patients with glioma.Methods The expression level of lncRNA FTX in glioma tissues obtained from 88 glioma patients who underwent microsurgery from January 2016 to January 2018 and in the tissues adjacent to glioma obtained from 46 glioma patients were detected using PCR,the glioma patients were divided into high expression group(n=57)and low expression group(n=31)based on the mean level of lncRNA FTX in glioma tissues.The patients were followed up for 3 years and the main endpoints were progression free survival and overall survival.Results The expression level of lncRNA FTX in glioma tissues was significantly higher than that in the tissues adjacent to glioma(P<0.05).Multivariate Cox proportional regression risk model analysis showed that high expression of lncRNA FTX was an independent risk factor for poor survival prognosis of glioma patients(RR=1.589;95%CI 1.004~2.515;P=0.048).Survival curve analysis showed that progression free survival(15.10 months)and overall survival(20.24 months)in the high expression group were significantly shorter than those(18.96 and 25.53 months,respectively)in the lower expression group(P<0.05).Conclusions Human gliomas express high level of lncRNA FTX,which is related to poor survival prognosis.