摘要
Objective:To study the relationship of interleukin-12(IL-12)and IL-4 levels with macroangiopathy in type 2 diabetes mellitus by comparing the serum IL-12 and IL-4 levels and intima-media thickness(IMT)between the healthy controls and the type 2 diabetic patients with or without macroangiopathy.Methods:30 healthy controls and 120 cases with type 2 diabetes mellitus from November 2011 to November 2012 were selected.In accordance with the carotid intima-media thickness,the type 2 diabetes mellitus patients were divided into group A with IMT below 1.0 mm,group B with IMT between 1.0 mm and 1.2 mm,group C with IMT between 1.2 mm and 1.4 mm,group D with IMT over 1.4 mm.ELISA was used to measure the levels of serum IL-12 and IL-4 in all groups.And the measurement results of serum IL-12 and IL-4 levels in the groups were compared.Results:Type 2 diabetes mellitus groups had significantly higher serum IL-12 levels and much lower IL-4 levels than the healthy control group.In the type 2 diabetes mellitus groups,the thicker the IMT was,the higher the incidence of complications became.IL-12 level was positively correlated with IMT while the IL-4 level was negatively correlated with IMT.Conclusions:IL-12 levels in patients with type 2 diabetes were significantly higher and IL-4 levels were significantly lower than those in the healthy people.In patients with type 2 diabetes,the IL-12 levels increased while the IL-4 levels gradually declined with the advance of macroangiopathy.
