Notch信号通路在眼科疾病发生发展中的调控作用

Research advances in the regulatory role of Notch signaling pathway in the occurrence and development of eye diseases

Notch信号通路是一种进化上高度保守的信号通路,广泛存在于各类组织细胞中,在胚胎发育、细胞增殖、分化和凋亡,维持多细胞生物稳态、血管生成以及多种癌症的发生发展过程中起重要作用。近年来研究发现Notch信号通路在白内障、葡萄膜炎、视网膜病变等多种眼科疾病中会表现为异常活化,调控着相关眼科疾病的发生和发展过程。本文就Notch信号通路在眼科疾病发生发展过程中的调控作用做简要综述。

The Notch signaling pathway is an evolutionarily highly conserved signaling pathway that exists in a wide variety of tissue cells and plays an important role in embryonic development,cell proliferation,differentiation and apoptosis,as well as in the maintenance of multicellular biosynthesis,angiogenesis,and the development of various cancers.In recent years,it has been found that the Notch signaling pathway is abnormally activated in cataract,uveitis and other ophthalmic diseases,regulating the process of ocular disease development.This article provides a brief review of the regulatory role of the Notch signaling pathway in the development of ophthalmic diseases.