调节破骨细胞功能的相关信号分子的研究进展

Research progress of signal molecules regulating osteoclast function

破骨细胞(osteoclast,OC)蚀骨能力是骨骼发育和骨骼重塑的重要细胞功能。大多数病理性骨病,如骨质疏松症,反映出破骨细胞数量、活性和骨吸收能力增加。由于破骨细胞数量和活性的增加会导致骨结构受损和骨量降低,这是骨质疏松症等骨疾病的共同特征,因此抑制破骨细胞分化是预防和/或治疗骨疾病及相关骨折的治疗策略之一。阐明破骨细胞诱导骨吸收的分子机制以及调节破骨细胞活性的信号分子,将为通过抑制骨吸收改善病理性骨疾病的药物开发提供参考。本文就破骨细胞的分化、活性和吸收功能信号分子的近期研究进展作一综述。

The ability of osteoclasts to erode bone is an important cellular function of bone development and bone remodeling.Most pathological bone diseases,such as osteoporosis,reflect an increase in the number,activity and absorptive capacity of osteoclasts.The increase of osteoclast number and activity will lead to the damage of bone structure and the decrease of bone mass,which are the common characteristics of bone diseases such as osteoporosis.Therefore,inhibiting osteoclast differentiation is one of the treatment strategies to prevent and/or to treat bone diseases and related fractures.Elucidating the molecular mechanism of osteoclast-induced bone resorption and the signal molecules regulating osteoclast activity will provide reference for drug development for bone diseases by inhibiting bone resorption.In this paper,the recent research progress of osteoclast differentiation,activity,and absorption function signal molecules is reviewed.