摘要
Coagulopathy,characterized by a high D-dimer level,is a common pathological occurrence in coronavirus dis-ease 2019(COVID-19)and is associated with poor prognosis.Severe cases with COVID-19 is associated with a significantly higher risk of deep vein thrombosis and acute pulmonary embolism.Pulmonary intravascular coagulopathy is the characteristic coagulopathy in COVID-19.Unlike sepsis-induced coagulopathy and dissem-inated intravascular coagulation,which are manifestations of systemic coagulopathy,pulmonary intravascular coagulopathy is a manifestation of a local coagulation disorder in the lung.The progression from pulmonary intravascular coagulopathy to sepsis-induced coagulopathy or disseminated intravascular coagulation in the con-text of COVID-19 may indicate that the patient’s coagulation dysfunction has progressed from local to systemic.Exploring the associated coagulation disease will aid in the understanding of the pathophysiological mechanisms underlying severe COVID-19.
基金
This work was supported by the Scientific Project of The Educational Department of Liaoning Province(Grant no.ZF2019010)
China Medical University’s COVID-19 prevention-and control-related research projects.
