安徽省沿江地区老年居民尿液金属水平与高血压的关联研究

Association between Levels of Various Metals in Urine and Hypertension in Older Population

目的探讨老年人群尿中金属水平与高血压的关联。方法从2014年9月至2015年6月,使用多阶段分层整群抽样的方法选取老年居民673人作为研究对象,晨尿中镉检测运用石墨炉原子吸收光谱法,尿铬、铜、铁、锰、锌、砷及铅检测采用电感耦合等离子体发射光谱仪。结果673名老年居民中高血压患者216例,患病率为32.1%。经过肌酐校正后,高血压组尿液铁、铜、铅、锰及锌元素的含量高于非高血压组。使用二元logistic回归拟合单金属模型显示,尿液中铜、锰、锌、铅含量越高,高血压的患病风险越大,相应的OR值及其95%CI分别为:2.11(1.26~3.52)、1.67(1.00~2.79)、2.70(1.61~4.52)、1.85(1.09~3.12)。结论尿中较高浓度的铜、锰、铅、锌可能会增加老年人群患高血压的风险,这为当地高血压的防控提供科学依据。

Objective To research the association between urinary metal level and hypertension in older population.Methods From September 2014 to June 2015,673 older residents were investigated by multi-stage stratified cluster sampling.We detected cadmium in morning urine by graphite furnace atomic absorption spectrometry,and chromium,copper,iron,manganese,zinc,arsenic and lead were detected by inductively coupled plasma emission spectrometer.Results 216 of 673 older residents had hypertension,the prevalence was 32.1%.The levels of copper,manganese,zinc and lead in urine in the hypertension group were higher than those in the non-hypertension group after creatinine correction.High concentrations of arsenic,chromium and lead in urine increased the risk of hypertension.The corresponding OR ratio and its 95%confidence interval(CI)are:2.11(1.26~3.52),1.67(1.00~2.79),2.70(1.61~4.52),1.85(1.09~3.12).Conclusion Higher concentrations of copper,manganese,lead,and zinc in urine may increase the risk of hypertension in older residents,which provides a scientific basis for the prevention and control of local hypertension.