小儿支气管哮喘急性发作采用布地奈德联合沙丁胺醇雾化吸入治疗的安全性评价

Safety Evaluation of Budesonide Combined with Salbutamol Nebulized Inhalation Therapy for Acute Exacerbation of Bronchial Asthma in Children

目的研究布地奈德与沙丁胺醇雾化吸入治疗支气管哮喘急性发作患儿的效果。方法于该院2019年2月—2020年4月收治的急性发作的支气管哮喘患儿中随机选取98例,按照到院时间的奇偶性,等分为对照组、观察组,各49例。对照组:单纯应用沙丁胺醇雾化吸入治疗,观察组:对照组基础上加用布地奈德。对比两组临床疗效、血清炎性因子、肺功能情况、不良反应发生率。结果两组临床疗效对比,观察组(97.96%)高于对照组(83.67%),差异有统计学意义(χ^(2)=4.404,P<0.05)。治疗前,两组炎性因子差异无统计学意义(t=0.277、0.064、0.161,P>0.05);治疗后,两组均改善,且观察组血清免疫球蛋白E、C反应蛋白、白介素-6较对照组低,差异有统计学意义(t=13.109、7.421、8.507,P<0.05)。治疗前,两组的肺功能指标对比,差异无统计学意义(t=0.109、0.300,P>0.05);治疗后,两组的肺功能都得到改善,两组肺功能比较,差异有统计学意义(t=2.333、6.217,P<0.05)。两组不良反应发生率对比,观察组更低,差异有统计学意义(χ^(2)=4.404,P<0.05)。结论布地奈德与沙丁胺醇治疗支气管哮喘疗效显著。

Objective To study the effect of nebulized inhalation of budesonide and salbutamol in the treatment of children with acute bronchial asthma.Methods From February 2019 to April 2020 in the hospital,98 children with acute onset of bronchial asthma were randomly selected.According to the parity of arrival time,they were equally divided into control group and observation group,with 49 cases in each group,the control group:aerosol inhalation treatment with salbutamol alone,and the observation group:budesonide in addition to the control group.The clinical efficacy,serum inflammatory factors,lung function,and incidence of adverse reactions were compared between the two groups.Results The clinical efficacy of the two groups was compared,and the observation group(97.96%)was higher than that of the control(83.67%),the difference was statistically significant(χ^(2)=4.404,P<0.05).Before treatment,there was no statistically significant difference in inflammatory factors between the two groups(t=0.277,0.064,0.161,P>0.05);after treatment,both groups improved,and the observation group's serum immunoglobulin E,C-reactive protein,and interleukin-6 were compared with the control group was lower,the difference were statistically significant(t=13.109,7.421,8.507,P<0.05).Before treatment,the pulmonary function indexes of the two groups were statistically compared,and there were no statistically significant(t=0.109,0.300,P>0.05);after treatment,the pulmonary function of the two groups were improved,comparison of lung function between the two groups,the difference was statistically significant(t=2.333,6.217,P<0.05).The incidence of adverse reactions between the two groups was compared,and the observation group was lower,the difference was statistically significant(χ^(2)=4.404,P<0.05).Conclusion Budesonide and salbutamol are effective in treating bronchial asthma.