在超声介入下注入聚氧乙烯月桂醇醚(聚桂醇)硬化剂治疗剖宫产瘢痕妊娠的临床效果分析

The Clinical Effect Analysis of Injecting Polyoxyethylene Laureth(Polycinnamyl Alcohol)Sclerosing Agent under Ultrasound Intervention in the Treatment of Cesarean Section Scar Pregnancy

目的探讨在超声介入下注入聚氧乙烯月桂醇醚(聚桂醇)硬化剂治疗剖宫产瘢痕妊娠(CSP)的效果。方法2019年8月—2020年10月搜集患者库CSP并方便选出92例分组,清宫术下,参照组46例行甲氨蝶呤肌内注射,研究组46例在超声介入下注入聚氧乙烯月桂醇醚(聚桂醇)硬化剂。归纳手术情况、术后发热发生率、疼痛(VAS)、恢复情况,对比。结果研究组手术用时相对于参照组较短,阴道出血量相对于参照组较少[(36.85±7.13)min vs(47.28±13.66)min,(351.20±13.42)mL vs(518.69±31.57)mL],差异有统计学意义(t=4.591、33.115,P<0.05);研究组发热发生率、术后VAS分值相对于参照组均较低[4.35%vs 19.57%,(3.15±0.75)分vs(5.48±0.63)分],差异有统计学意义(χ^(2)=5.060,t=16.134,P<0.05);恢复情况对比血β-人绒毛膜促性腺激素(HCG)水平降至正常时间、出院时间、月经恢复正常时间,研究组数值相对于参照组均较短[(34.18±2.24)d vs(42.79±4.18)d,(1.07±0.44)d vs(2.25±0.39)d,(32.55±2.51)d vs(41.07±4.61)d],差异有统计学意义(t=12.314、13.612、11.009,P<0.05)。结论超声介入下注入聚氧乙烯月桂醇醚(聚桂醇)硬化剂治疗CSP可减少清宫术出血量,降低发热发生率,还能缓解术后疼痛,加快患者康复进程。

Objective To discuss the therapeutic effect of injecting polyoxyethylene laureth(polycinnamyl alcohol)sclerosing agent under ultrasound intervention in the treatment of cesarean section scar pregnancy(CSP).Methods From August 2019 to October 2020 the patient database of CSP patients was collected and 92 cases were conveniently selected.Under uterine evacuation,46 cases in the reference group received intramuscular injection of methotrexate,and 46 cases in the study group was injected with polyoxyethylene under ultrasound intervention laureth(polycinnamyl alcohol)hardener.Summarized and compared the operation status,postoperative fever incidence,pain(VAS),recovery status.Results The operation time of the study group was shorter than that of the reference group,and the amount of vaginal bleeding was less than that of the reference group[(36.85±7.13)min vs(47.28±13.66)min,(351.20±13.42)mL vs(518.69±31.57)mL],the difference was statistically significant(t=4.591,33.115,P<0.05);the incidence of fever and postoperative VAS scores in the study group were lower than those in the reference group[(4.35%vs 19.57%),(3.15±0.75)points vs(5.48±0.63)points],the difference was statistically significant(χ^(2)=5.060,t=16.134,P<0.05);comparison of recovery conditions:time when bloodβ-human chorionic gonadotropin(HCG)level drops to normal,time to discharge,time to return to normal menstruation,the value of the study group was relative shorter to the reference group[(34.18±2.24)d vs(42.79±4.18)d,(1.07±0.44)d vs(2.25±0.39)d,(32.55±2.51)d vs(41.07±4.61)d],the difference was statistically significant(t=12.314,13.612,11.009,P<0.05).Conclusion Infusion of polyoxyethylene laureth(polycinnamyl alcohol)sclerosant for CSP under ultrasound intervention can reduce blood loss during uterine evacuation,reduce the incidence of fever,relieve postoperative pain,and speed up the recovery process of patients.