肿瘤PET乏氧显像的临床研究进展

Clinical research progress of PET imaging in tumor hypoxia

乏氧是实体瘤的常见现象,与肿瘤的增殖、恶性进展、放化疗抵抗、耐药性、治疗失败、不良预后密切相关。目前较多的相关研究集中于应用影像学、核医学方法检测肿瘤乏氧区域方面。该文对肿瘤乏氧微环境的检测及多种PET显像剂应用于肿瘤乏氧显像的研究进展进行综述。

Hypoxia is a common phenomenon of solid tumor,which is closely related to the malignant proliferation,tumor progression,radiotherapy and chemotherapy resistance,treatment failure,and poor prognosis.At present,many researches focus on the application of medical imaging and nuclear medicine methods in detecting the hypoxic areas of tumors.This article focuses on the detection of hypoxia microenvironment and the application of PET tracers in tumor hypoxia imaging.