肠-肺轴的中医内涵及临床意义

Traditional Chinese medicine connotation and clinical significance of gut-lung axis

结合中医理论及现代研究,探讨肠-肺轴的中医内涵及临床意义。肠与肺位置相近、以膈为界,具有津液同调、营养共需、共同参与机体免疫防护等功能。肠道菌群对肺的生理、病理均有一定影响,通过调节肠道菌群可治疗多种肺部疾病,并影响机体肺、肠免疫。虽然肺肠之间津液代谢的物质基础和信号连接尚未明晰,但随着现代科学技术的发展,肠-肺轴的现代知识架构终将形成,临床意义深远。

Traditional Chinese medicine(TCM)connotation and clinical significance of gut-lung axis was discussed based on the combination of TCM theory and modern medical research.The anatomical position of intestine and lung is close,with diaphragm as the boundary.Therefore,intestine and lung have the functions of regulating body fluid,sharing nutrition and nourishment,and participating in immune protection.Intestinal flora has certain influence on the lung physiology and pathology.Regulating intestinal flora can facilitate the treatment of multiple lung diseases and affect the lung and gut immunity.Although the material basis and signaling pathways of body fluid metabolism between the lung and intestine are not clear yet,the modern intellectual framework of gut-lung axis,which has profound clinical significance,will eventually be formed with the development of modern science and technology.