中药对肺纤维化相关机制调控的研究进展

Research progress on related mechanism regulation by traditional Chinese herbal medicine in pulmonary fibrosis

综述中药对肺纤维化相关机制调控的实验研究进展。研究发现,中药的经方、复方、单体及有效成分在介导氧化/抗氧化应激、抑制上皮细胞-间充质转化、抑制内质网应激、介导细胞自噬、改善细胞外基质沉积、调节免疫平衡等方面发挥治疗肺纤维化的作用。

The research progress on related mechanism regulation by traditional Chinese herbal medicine in pulmonary fibrosis was reviewed.Studies had found that classical prescriptions,compound prescriptions,monomers and active ingredients played a therapeutic role in pulmonary fibrosis on mediating oxidative/anti-oxidative stress,inhibiting epithelial cell-mesenchymal transition,inhibiting endoplasmic reticulum stress,mediating autophagy,improving extracellular matrix deposition and regulating immune balance.