Copper-mediated polyurethane materials with enzyme-like catalysis for biocompatibility improvement in blood environments

Because of their good performance,including biocompatibility and mechanical proper-ties,polyurethanes(PUs)are widely used in medical devices.However,undesired compatibility troubles,including thrombus,inflammation,and hyperplasia,still limit the applications of PUs.In this study,copper-mediated polyurethane(PU-Cu)materials with enzyme-like catalysis were prepared.The PU-Cu materials effectively catalysed the nitric oxide(NO)released from endogenous NO donors because of the glutathione peroxidase(GPx)-like function of copper ion.The PU‐Cu materials were respectively evaluated via platelet adhesion and endothelial cell(EC),smooth muscle cell(SMC),and macrophage(MA)cultures.Scanning electron microscopy results showed that PU-Cu materials significantly inhibited platelet adhesion and activation.Meanwhile,PU-Cu materials not only promote the proliferation of EC but also inhibit SMC growth.Moreover,MA culture results intuitively stated the anti-inflammatory ability of PU-Cu.In addition,experimental samples were implanted into the subcutaneous tissue of Sprague Dawley rats.The anti-inflammatory function of PU-Cu was further confirmed by haematoxylin-eosin staining results.With regard to their excellent biological performance,PU-Cu materials are proposed for biocompatibility improvement of blood-contacting mate-rials,which should in turn provide new ideas for advanced medical devices.