慢性阻塞性肺疾病(慢阻肺)合并肺部感染患者实施盐酸氨溴索治疗的效果观察

Observation on the Effect of Ambroxol Hydrochloride in the Treatment of Chronic Obstructive Pulmonary disease (COPD) Complicated with Pulmonary Infection

目的观察慢性阻塞性肺疾病(慢阻肺)合并肺部感染患者实施盐酸氨溴索治疗的效果分析。方法将在我院就诊,近期(2019年2月至2020年6月时期)收治慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)合并肺部感染患者总计80例随机数字法分成两组每组各40例患者,均接受常规治疗,其中40例不接受其他治疗为对照组,另40例合并盐酸氨溴索治疗为试验组。对照两组患者治疗前、后感染指标血气指标与肺功能指标,临床症状消失时间,治疗疗效。结果在治疗后炎性指标、血气指标中PaCO_(2)较治疗前降低,且试验组低于对照组,而血气指标中PaO_(2)、肺功能指标均较治疗前升高,且试验组高于对照组。试验组患者在治疗后的临床症状消失时间均短于对照组。试验组患者的治疗总有效率92.50%高于对照组72.50%,差异(P<0.05)有意义。结论在慢性阻塞性肺疾病(慢阻肺)合并肺部感染患者治疗中,以盐酸氨溴索治疗,可明显的降低血液感染指标,提升肺功能指标,改善血气指标,缩短临床症状的消失时间,提升治疗总有效率,效果理想有在临床上普及、推广、使用价值。

Objective To observe the effect of ambroxol hydrochloride in the treatment of chronic obstructive pulmonary disease (COPD) with pulmonary infection.Methods We will treat patients with chronic obstructive pulmonary disease (COPD) in our hospital in the near future (from February 2019 to June 2020) A total of 80 patients with chronic obstructive pulmonary disease (COPD) complicated with pulmonary infection were randomly divided into two groups with 40 patients in each group.All patients received conventional treatment,40 patients did not receive other treatment as the control group,and the other 40 patients combined with ambroxol hydrochloride treatment as the experimental group.Before and after treatment,the infection index,blood gas index,lung function index,clinical symptom disappearance time and treatment effect of the two groups were compared.Results After treatment,PaCO_(2) in inflammatory indexes and blood gas indexes were lower than before treatment,and the experimental group was lower than the control group,while PaO_(2) and lung function indexes in blood gas indexes were higher than before treatment,and the experimental group was higher than the control group.The disappearance time of clinical symptoms in the experimental group was shorter than that in the control group.The total effective rate of the experimental group was 92.50%,which was higher than 72.50% of the control group (P<0.05).Conclusion In the treatment of patients with chronic obstructive pulmonary disease (COPD) combined with pulmonary infection,ambroxol hydrochloride treatment can significantly reduce blood infection index,improve lung function index,improve blood gas index,shorten the disappearance time of clinical symptoms,improve the total effective rate of treatment,the effect is ideal,and has the value of popularization,promotion and use in clinic.