猪毛蒿化学成分及羟甲香豆素药理作用研究进展

Research advance on the chemical constituents of Artemisia scoparia Waldst.et Kit.and the pharmacological effects of hymecromone

猪毛蒿为菊科多年生草本植物,具有药食同源功效。传统中医取其经干燥后的地上部分用于治疗疾病,具有清热利湿、退黄、利胆护肝等功效。目前从猪毛蒿中分离鉴定出的化学成分可分为香豆素类、挥发油类、黄酮类和有机酸及脂肪酸类等。现代研究表明,猪毛蒿中的羟甲香豆素具有广泛的药理活性,具有利胆、解痉、镇痛、抗炎等药理作用,还在抗肿瘤、抗肝纤维化以及治疗慢性粒细胞白血病等疾病方面发挥着重要的作用。本文主要对猪毛蒿的化学成分进行总结,并对其活性成分羟甲香豆素药理作用进行综述,以期为猪毛蒿及羟甲香豆素的深入研究、开发和临床应用提供参考。

Artemisia scoparia Waldst.et Kit.is a perennial herb of the Compositae family,which has the same medicinal and food effects.In traditional Chinese medicine,the dried aerial parts are used to treat diseases,and have the effects of clearing heat and dampness,reducing jaundice,and protecting the liver.At present,the chemical components identified from A.scoparia can be divided into coumarins,volatile oils,flavonoids,organic acids and fatty acids.Modern studies have shown that the hymecromone in A.scoparia has a wide range of pharmacological activities.It has pharmacological effects such as choleretic,antispasmodic,analgesic and anti-inflammatory.It is also anti-tumor,anti-liver fibrosis and treatment chronic myeloid leukemia and other diseases play an important role.This article mainly summarizes the chemical components of A.scoparia and summarizes the pharmacological effects of hymecromone,in order to provide references for the in-depth research,development and clinical application of A.scoparia and hymecromone.